2. Immunology/Inflammation
  3. Mucin
  4. Surzebiclimab

Surzebiclimab  (Synonyms: BGB-A425)

目录号: HY-P99962 纯度: 95.00%
COA 技术支持

Surzebiclimab (BGB-A425) 是一种人源化 IgG1 变体单克隆抗体，抗 T 细胞免疫球蛋白和含粘蛋白结构域 3 (TIM-3)。Surzebiclimab 与人 Tim-3 细胞外结构域结合具有较高的亲和力 (KD=0.36 nM) 和特异性。Surzebiclimab 可用于癌症研究。

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CAS No. : 2342597-90-2

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规格 价格 是否有货 数量
1 mg ￥3500
In-stock
5 mg ￥9100
In-stock
10 mg   询价  
50 mg   询价  

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Surzebiclimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
体外研究
(In Vitro)

Surzebiclimab (BGB-A425; 0.1-100 μg/mL) 有效阻断 Tim-3 和 PtdSer 之间的相互作用。Surzebiclimab 增强原代 T 细胞的 IFN-γ 产生和 NK 介导的对肿瘤细胞的细胞毒性[1]。
Surzebiclimab 单独或与抗 PD-1 抗体 BGB-A317 联合使用可增强 T 细胞对同种异体抗原的反应。Surzebiclimab 还可以诱导细胞表面 Tim-3 受体的内化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Surzebiclimab 相关抗体:
体内研究
(In Vivo)

surzebiclimb (BGB-A425) 联合 BGB-A317 在小鼠异种移植瘤模型中抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

145.72 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献

Surzebiclimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Surzebiclimab2342597-90-2BGB-A425Mucinhumanized monoclonal antibodyIFN-γprimary T cellsNK-mediated cytotoxicitycancerInhibitorinhibitorinhibit

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