2. Immunology/Inflammation
  3. Complement System
  4. Sutimlimab

Sutimlimab  (Synonyms: 苏替莫单抗)

目录号: HY-P99050 纯度: 98.81%
COA 技术支持

Sutimlimab 是一种人源化单克隆 IgG4 抗体。Sutimlimab 可抑制补体蛋白成分 1 的亚成分 (C1s)。Sutimlimab 可阻断 C3 和 C4 的激活。Sutimlimab 可用于冷凝集素病和补体介导的溶血性尿毒症综合征的研究。

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CAS No. : 2049079-64-1

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥7800
In-stock
10 mg   询价  
50 mg   询价  

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Sutimlimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sutimlimab is a humanized monoclonal IgG4 antibody. Sutimlimab inhibits complement protein component 1, s subcomponent (C1s). Sutimlimab blocks C3 and C4 activation. Sutimlimab can be used for the research of cold agglutinin disease and complement-mediated hemolytic uremic syndrome[1][2][3].

同型

Human IgG4 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

C1s
体外研究
(In Vitro)

Sutimlimab (30 μg/mL) 可以显著保护 CD46KO 细胞免于补体介导的细胞死亡，相对 1 h 发光恢复率为 73%[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sutimlimab 相关抗体:
Clinical Trial
基因 ID

716  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

144.8 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

苏替莫单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized C1s/Complement component C1s Protein, Human can bind Sutimlimab. The EC50 for this effect is 16.31 ng/mL.
纯度 & 产品资料
参考文献

Sutimlimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sutimlimab2049079-64-1苏替莫单抗Complement Systemcomplement protein component 1s subcomponentC1s inhibitorcold agglutinin diseaseInhibitorinhibitorinhibit

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