Syk-IN-8

目录号: HY-155513: Data Sheet 产品使用指南
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Syk-IN-8 (compound 19q) 是一种 Syk 抑制剂，对多种血液肿瘤细胞具有抗增殖活性。Syk-IN-8 抑制 PLCγ2 磷酸化，可用于血癌研究。

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Syk-IN-8 Chemical Structure

CAS No. : 2568963-01-7

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生物活性

Syk-IN-8 (compound 19q) is a Syk inhibitor, with antiproliferative activity against multiple hematological tumour cells. Syk-IN-8 inhibits PLCγ2 phosphorylation, can be used for research in blood cancers^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
DOHH-2	IC₅₀	8.68 nM Compound: 19q	Antiproliferative activity against human DOHH-2 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human DOHH-2 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 37423126]
Daudi	IC₅₀	719 nM Compound: 19q	Antiproliferative activity against human Daudi cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human Daudi cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 37423126]
MV4-11	IC₅₀	1.5 nM Compound: 19q	Inhibition of cell viability in human MV4-11 cells incubated for 72 hrs by Cell Titer Glo assay Inhibition of cell viability in human MV4-11 cells incubated for 72 hrs by Cell Titer Glo assay	[PMID: 37423126]
Ramos	IC₅₀	18 nM Compound: 19q	Inhibition of cell growth in serum-starved human Ramos cells incubated for 1 hr followed by anti-human IgM F(ab)2 measured after 5 mins Inhibition of cell growth in serum-starved human Ramos cells incubated for 1 hr followed by anti-human IgM F(ab)2 measured after 5 mins	[PMID: 37423126]
Rec1	IC₅₀	34.3 nM Compound: 19q	Antiproliferative activity against human REC1 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human REC1 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 37423126]
SU-DHL-6	IC₅₀	216 nM Compound: 19q	Antiproliferative activity against human SU-DHL-6 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human SU-DHL-6 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 37423126]
TMD8	IC₅₀	10.9 nM Compound: 19q	Antiproliferative activity against human TMD8 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human TMD8 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 37423126]

分子量

442.52

Formula

C₂₃H₂₆N₁₀

CAS 号

2568963-01-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Bingbing Cui, et al. Discovery of 3-(1H-benzo[d]imidazole-2-yl)-1H-pyrazol-4 -amine derivatives as novel and potent syk inhibitors for the treatment of hematological malignancies. European Journal of Medicinal Chemistry. Volume 258, 5 October 2023, 115597.

Syk-IN-8 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Syk-IN-82568963-01-7SykSpleen tyrosine kinaseInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Syk-IN-8

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Syk-IN-8 相关分类

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The molarity calculator equation

The dilution calculator equation

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