2. 寡核苷酸
  3. 核酸适配体
  4. SYL3C aptamer sodium

SYL3C aptamer sodium 是靶向癌细胞表面的上皮细胞粘附分子 (EpCAM) 的 DNA 核酸适配体。SYL3C aptamer sodium 靶向包括 MDA-MB-231、Kato III、HT-29、T47D 和 SW480 在内的多种人癌细胞系。SYL3C aptamer sodium 针对乳腺癌细胞 MDA-MB-231 和胃癌细胞 Kato III 的 Kd 分别为 38 nM 和 67 nM。SYL3C aptamer sodium 具有稳定性、高结合亲和力和选择性，可用于靶向癌症治疗、癌细胞成像和循环肿瘤细胞检测。

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DNA, 5'-CACTACAGAGGTTGCGTCTGTCCCACGTTGTCATGGGGGGTTGGCCTG-3', sodium salt

SYL3C aptamer sodium Chemical Structure

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SYL3C aptamer sodium 相关抗体

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生物活性

SYL3C aptamer sodium is a DNA aptamer that targets the epithelial cell adhesion molecule (EpCAM) on the surface of cancer cells. SYL3C aptamer sodium targets multiple human cancer cell lines including MDA-MB-231, Kato III, HT-29, T47D and SW480. The Kd of SYL3C aptamer sodium against breast cancer cell line MDA-MB-231 and gastric cancer cell line Kato III is 38 nM and 67 nM, respectively. SYL3C aptamer sodium provides stability, high binding affinity, and selectivity for targeted cancer therapy, cancer cell imaging, and circulating tumor cell detection[1].

IC50 & Target

Epithelial cell adhesion molecule (EpCAM)[1]
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SYL3C aptamerOthersDNA aptamersstabilityhigh binding affinity and selectivityInhibitorinhibitorinhibit

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