2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. TAN-67 dihydrobromide

TAN-67 dihydrobromide  (Synonyms: SB-205607 dihydrobromide)

目录号: HY-101317 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

TAN-67 (SB-205607) dihydrobromide 是一种有效的选择性非肽类 δ-阿片受体 (δ-opioid receptor) 激动剂，Ki 值为 0.647 nM。TAN-67 dihydrobromide 具有神经保护作用。TAN-67 dihydrobromide 可用于缺血性脑卒中的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

TAN-67 dihydrobromide Chemical Structure

TAN-67 dihydrobromide Chemical Structure

CAS No. : 1217628-73-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2181
In-stock
5 mg ￥4800
询价
10 mg ￥7680
询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

TAN-67 dihydrobromide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TAN-67 (SB-205607) dihydrobromide is a potent and selective nonpeptidic δ-opioid receptor agonist with a Ki value of 0.647 nM. TAN-67 dihydrobromide has neuroprotective effect. TAN-67 dihydrobromide can be used in research of ischemic stroke[1][2].

IC50 & Target[1]

δ Opioid Receptor/DOR

0.647 nM (Ki)

体外研究
(In Vitro)

TAN-67 (SB-205607) dihydrobromide 高效 (EC50 = 1.72 nM) 抑制毛喉素刺激的 cAMP 在由完整的中国仓鼠卵巢细胞表达的人 delta-阿片受体上的积累，但在人 mu-阿片受体上的效力较低 (EC50 = 1520 nM)由完整的 B82 小鼠成纤维细胞表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TAN-67 dihydrobromide 相关抗体:
体内研究
(In Vivo)

TAN-67 (SB-205607; 1.5-4.5 mg/kg; i.v.; once) dihydrobromide 减少 I/R 引起的脑损伤的梗塞体积[2]。
TAN-67 (3 mg/kg; i.v.; once) dihydrobromide 改善 I/R 后的生存和神经行为表现[2]。
TAN-67 (3 mg/kg; i.v.; once; 成年 C57BL/6J 雄性小鼠) dihydrobromide 在早期时间点 (6 h) 增加总 APP 和成熟 APP (APPm) 水平和 APP 处理[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult C57BL/6J male mice with I/R-caused brain injury[2]
Dosage: 1.5, 3.0, and 4.5 mg/kg
Administration: Intravenous injection; once
Result: Reduced infarct volume in a dose-dependent manner.
Animal Model: Adult C57BL/6J male mice with I/R-caused brain injury[2]
Dosage: 3.0 mg/kg
Administration: Intravenous injection; once
Result: Had rapidly functional recovery than the vehicle-treated mice.
Reduced neuronal cell death.
Animal Model: Adult C57BL/6J male mice with transient middle cerebra artery occlusion (MCAO) ischemic stroke model[2]
Dosage: 3.0 mg/kg
Administration: Intravenous injection; once
Result: Increased both total APP and mature APP (APPm) levels.
Reduced β-secretase activity.
分子量

506.27

Formula

C23H26Br2N2O
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

TAN-67 dihydrobromide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAN-67 dihydrobromide1217628-73-3SB-205607 dihydrobromideOpioid Receptornonpeptidicneuroprotectiveischemic strokeCamphamster ovary cellsB82 mouse fibroblast cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
TAN-67 dihydrobromide
目录号：
HY-101317
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z