2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. tcY-NH2

tcY-NH2  (Synonyms: (trans-Cinnamoyl)-YPGKF-NH2)

目录号: HY-P1263 纯度: 98.85%
COA 产品使用指南 技术支持

tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) 是一种有效的 PAR4 选择性肽类拮抗剂。tcY-NH2 抑制凝血酶和 AY-NH2 诱导的血小板聚集和内皮抑素释放，可用于炎症、免疫学的研究。

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Custom Peptide Synthesis

tcY-NH2

tcY-NH2 Chemical Structure

CAS No. : 327177-34-4

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规格 价格 是否有货 数量
1 mg ￥900
In-stock
5 mg ￥2600
In-stock
10 mg ￥4200
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of tcY-NH2:

tcY-NH2 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Protease Activated Receptor (PAR) 亚型特异性产品:

查看所有亚型
PAR1 PAR2 PAR4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) is a potent selective PAR4 antagonist peptide. tcY-NH2 inhibits thrombin- and AY-NH2-induced platelet aggregation and endostatin release, and can be used in the research of inflammation, immunology[1][2][6].

IC50 & Target

PAR4

 

体外研究
(In Vitro)

tcY-NH2 (0-500 μM) inhibits AYPGKF-NH2 (10 μM)-induced platelet (obtained from male albino Sprague–Dawley rats) aggregation, with an IC50 value of 95 μM[1].
tcY-NH2 potently activates aorta relaxation (RA) and gastric (LM) contraction, with IC50 values of 64 μM (RA) and 1 μM (LM)[1].
tcY-NH2 (Tc-YPGKF-NH2, 400 μM, 5 min) prevents endostatin release and platelet aggregation induced by thrombin or by AY-NH2[2].
tcY-NH2 (5 μM, 15 min) decreases infarct size (IS) by 51%, and increases recovery of ventricular function by 26% in an isolated heart model[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

tcY-NH2 相关抗体:
体内研究
(In Vivo)

tcY-NH2 (tail vein injection, 0.6 mg/kg for a single dose) alleviates liver injury in Brain death (BD) rat model, indicated by lower serum ALT/AST levels and better histomorphology[3].
tcY-NH2 (intraperitoneal injection, 0.6 mg/kg for a single dose) increases posttraumatic activation of CD4+ Tregs within the draining lymph nodes in burn injury mice model [4].
tcY-NH2 (intrapleural injection, 40 ng/kg for a single dose) inhibits neutrophil recruitment in experimental inflammation in mice[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Brain death (BD) rat model[3]
Dosage: 0.6 mg/kg for a single dose
Administration: Tail vein injection for a single dose
Result: Reduced blood platelet activation and hepatic platelet accumulation.
Attenuated the inflammatory response and apoptosis in the livers.
Inhibited the activation of NF-κB and MAPK pathways induced by Brain death (BD).
Animal Model: Burn injury model of C57BL/6 N mice[4]
Dosage: 0.6 mg/kg for a single dose
Administration: Intraperitoneal injection
Result: Increased expression and phosphorylation of PKC-θ in the presence of platelets, without affecting early posttraumatic hemostasis.
Animal Model: BALB/c mice[6]
Dosage: 40 ng/kg for a single dose
Administration: Intrapleural injection
Result: Abolished the number of rolling and adhering neutrophils on the vessel wall.
Inhibited CXCL8- and Cg-induced neutrophil migration into the pleural cavity of mice.
分子量

739.86

Formula

C40H49N7O7
CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

{trans-Cinnamoyl}-YPGKF-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (135.16 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3516 mL 6.7580 mL 13.5161 mL
5 mM 0.2703 mL 1.3516 mL 2.7032 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

tcY-NH2 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3516 mL 6.7580 mL 13.5161 mL 33.7902 mL
5 mM 0.2703 mL 1.3516 mL 2.7032 mL 6.7580 mL
10 mM 0.1352 mL 0.6758 mL 1.3516 mL 3.3790 mL
15 mM 0.0901 mL 0.4505 mL 0.9011 mL 2.2527 mL
20 mM 0.0676 mL 0.3379 mL 0.6758 mL 1.6895 mL
25 mM 0.0541 mL 0.2703 mL 0.5406 mL 1.3516 mL
30 mM 0.0451 mL 0.2253 mL 0.4505 mL 1.1263 mL
40 mM 0.0338 mL 0.1690 mL 0.3379 mL 0.8448 mL
50 mM 0.0270 mL 0.1352 mL 0.2703 mL 0.6758 mL
60 mM 0.0225 mL 0.1126 mL 0.2253 mL 0.5632 mL
80 mM 0.0169 mL 0.0845 mL 0.1690 mL 0.4224 mL
100 mM 0.0135 mL 0.0676 mL 0.1352 mL 0.3379 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

tcY-NH2327177-34-4(trans-Cinnamoyl)-YPGKF-NH2Protease Activated Receptor (PAR)Thrombin receptorsPlateletthrombinthrombocytesinflammationimmunebrain death modelburn injury modelendostatinneutrophil migrationInhibitorinhibitorinhibit

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