2. PROTAC
  3. Ligands for E3 Ligase
  4. Thalidomide-4-O-CH2-COO(t-Bu)

Thalidomide-4-O-CH2-COO(t-Bu) 是t-Bu 修饰的 Thalidomide (HY-14658)，是合成 Thalidomide-4-OH (HY-123096) 的最后一步中间体。Thalidomide-4-O-CH2-COO(t-Bu) 可作为 Cereblon?配体，募集 CRBN?蛋白。Thalidomide-4-O-CH2-COO(t-Bu) 末端的 t-Bu 保护基团，可在酸性条件下脱除，进而参与 PROTAC 分子的合成。Thalidomide-4-O-CH2-COO(t-Bu) 是基于 CRBN 设计的 PROTAC 分子合成过程中的关键中间体。

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Thalidomide-4-O-CH2-COO(t-Bu) Chemical Structure

Thalidomide-4-O-CH2-COO(t-Bu) Chemical Structure

CAS No. : 1950635-36-5

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Thalidomide-4-O-CH2-COO(t-Bu) 相关抗体

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

  • 生物活性

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生物活性

Thalidomide-4-O-CH2-COO(t-Bu) is t-Bu modified Thalidomide (HY-14658), which is the final step intermediate in the synthesis of Thalidomide-4-OH (HY-123096). Thalidomide-4-O-CH2-COO(t-Bu) acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group at the end of Thalidomide-4-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules.

分子量

388.37

Formula

C19H20N2O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Thalidomide-4-O-CH2-COO(t-Bu) 相关分类

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Keywords:

Thalidomide-4-O-CH2-COO(t-Bu)1950635-36-5Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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