2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-NH-C2-PEG3-OH

Thalidomide-NH-C2-PEG3-OH 是一种 E3 连接酶配体-linker 偶联物 (E3 ligase ligand-linker conjugate)，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。用于合成 PROTAC BCL-XL 降解剂 XZ739。

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Thalidomide-NH-C2-PEG3-OH Chemical Structure

Thalidomide-NH-C2-PEG3-OH Chemical Structure

CAS No. : 2140807-23-2

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规格 价格 是否有货
1 mg ￥2210
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Thalidomide-NH-C2-PEG3-OH 相关抗体

Top Publications Citing Use of Products

查看 E3 Ligase Ligand-Linker Conjugates 亚型特异性产品:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-NH-C2-PEG3-OH 相关抗体:
分子量

449.45

Formula

C21H27N3O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Thalidomide-NH-C2-PEG3-OH 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-NH-C2-PEG3-OH2140807-23-2E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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产品名称：
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目录号：
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