2. GPCR/G Protein Neuronal Signaling
  3. Melatonin Receptor 5-HT Receptor
  4. TIK-301

TIK-301  (Synonyms: PD-6735; LY-156735)

目录号: HY-106136
产品使用指南

摩尔计算器

TIK-301 (PD-6735) 是一种氯化的褪黑激素衍生物，是一种有效的，高亲和力和口服活性的褪黑激素 MT1 和 MT2 受体激动剂，Ki 分别为 0.081 nM 和 0.042 nM。TIK-301 还是一种 5-HT2B/5-HT2C 受体拮抗剂，具有抗抑郁作用 。TIK-301 可用于睡眠障碍和其他昼夜节律障碍疾病的研究。

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TIK-301 Chemical Structure

TIK-301 Chemical Structure

CAS No. : 118702-11-7

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TIK-301 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment[1][2][3].

IC50 & Target

5-HT2C Receptor

 

5-HT2B Receptor

 

melatonin MT1

0.081 nM (Ki)

melatonin MT2

0.042 nM (Ki)

体内研究
(In Vivo)

In male rats, TIK-301(at doses of 0.8 and 4.0 mg/kg/day) can reduce body weight, and without altering food intake[1][2].
The Tmax and half-life of TIK-301 is 1.1 hour and 1 hour, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

280.75

Formula

C14H17ClN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TIK-301 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TIK-301118702-11-7PD-6735 LY-156735TIK301TIK 301PD6735PD 6735LY156735LY 156735LY-156735Melatonin Receptor5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorMelatoninMT1MT25-HT2B5-HT2CinsomniasedativechlorinatedantidepressantInhibitorinhibitorinhibit

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HY-106136
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