2. Apoptosis Protein Tyrosine Kinase/RTK
  3. Apoptosis SHP2
  4. TK-684

TK-684 是一种有效的、选择性的 SHP2 变构抑制剂，其对 SHP2WT 和 SHP22PTP 的 IC50 值分别 2.1，＞1000 nM。TK-684 可抑制细胞增殖并诱导细胞凋亡 (apoptosis)。TK-684 可降低 p-AKT 和 p-ERK 的蛋白表达。

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TK-684

TK-684 Chemical Structure

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TK-684 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TK-684 is a potent and selective allosteric SHP2 inhibitor with IC50 values of 2.1, ＞1000 nM for SHP2WT, SHP22PTP, respectively. TK-684 inhibits cell proliferation and induces apoptosis. TK-684 decreases the protein expression of p-AKT, p-ERK[1].

体外研究
(In Vitro)

TK-684 (1.25-100 μM; 72 小时) 抑制 KYSE-150 细胞增殖[1]。
TK-684 (0-40 μM; 48 小时) 诱导细胞凋亡[1]。
TK-684 (0-20 μM; 2 小时) 以剂量依赖性方式降低 p-AKT 和 p-ERK 的蛋白表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TK-684 相关抗体:

Cell Proliferation Assay[1]

Cell Line: KYSE-150 cells
Concentration: 1.25-100 μM
Incubation Time: 72 h
Result: Inhibited cell proliferative.

Apoptosis Analysis[1]

Cell Line: KYSE-150 cells
Concentration: 0-40 μM
Incubation Time: 48 h
Result: Induced cell apoptosis.

Western Blot Analysis[1]

Cell Line: KYSE-150 cells
Concentration: 0-20 μM
Incubation Time: 2 h
Result: Decreased the protein expression of p-AKT, p-ERK in a dose-dependent manner.
药代动力学
(Parmacokinetics)
Species Dose Route Indicator value
Rat 10 mg/kg p.o. T1/2 (Metabolic) 2.41 hr
Rat 10 mg/kg p.o. F 0.9 %
分子量

420.92

Formula

C17H21ClN8OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TK-684 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TK-684TK684TK 684ApoptosisSHP2Src homology phosphatase 2PTPN11KYSE-150 cellsapoptosisp-AKTp-ERKproliferationInhibitorinhibitorinhibit

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目录号：
HY-173573
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