2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. TM6008

TM6008 是一种有效的，具有口服活性的脯氨酸羟化酶 (PHD) 抑制剂。TM6008 螯合过渡金属(铜)，抑制抗坏血酸自氧化， IC50 值为 0.57 μM。TM6008 在体内对缺血有器官保护作用，可用于脑血管疾病研究。

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TM6008 Chemical Structure

TM6008 Chemical Structure

CAS No. : 945008-17-3

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TM6008 相关抗体

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查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

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HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TM6008 is a potent and orally active prolyl hydroxylase (PHD) inhibitor. TM6008 chelats transition metal (copper) and inhibits the autoxidation of ascorbic acid with an IC50 value is 0.57 μM. TM6008  exerts organ protection against ischemia in vivo and can be used for cerebrovascular disease research[1].

体内研究
(In Vivo)

TM6008 (p.o.; 50 mg/kg; single dosage) exhibits plasma Tmax, Cmax, and T1/2 values of 3.5 hour, 0.9 μg/mL and 1.5 hour for TM6008 in rat[1].
TM6008 (p.o.; 100 mg/kg; 7 days) protects against hypoxia-induced apoptotic neuronal death and decreases the number of apoptotic cells in Gerbils after a 5-minute transient global cerebral ischemia[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Gerbils after a 5-minute transient global cerebral ischemia[1]
Dosage: 100 mg/kg
Administration: p.o.; 100 mg/kg; 7 days
Result: Exerted organ protection against ischemia in vivo.
分子量

387.39

Formula

C21H17N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TM6008 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TM6008945008-17-3TM 6008TM-6008HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHHypoxia inducible factorHIFischemiccerebrovascular diseaseangiogenesisInhibitorinhibitorinhibit

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