2. Anti-infection
  3. HCV
  4. TMC647055

TMC647055 是一种有效的 HCV 复制的非核苷 NS5B 聚合酶抑制剂。TMC647055 具有较强的 HCV 结合活性，其 IC50 值为 82 nM。TMC647055 可用于丙型肝炎病毒 (HCV) 的研究。

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TMC647055 Chemical Structure

TMC647055 Chemical Structure

CAS No. : 1204416-97-6

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TMC647055 的其他形式现货产品:

Customer Review

Other Forms of TMC647055:

TMC647055 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TMC647055 is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication. TMC647055 has potent HCV combine activity with an IC50 value of 82 nM. TMC647055 can be used for the research of Hepatitis C virus (HCV)[1][2].

IC50 & Target

EC90: 0.3 μM (Huh7-Luc cell)[1].
EC50: 82 nM (HCV)[2]
体外研究
(In Vitro)

TMC647055 has antiviral activity with an EC90 value of 0.3 μM in Huh7-Luc cells[1].
TMC647055 has potent combine activity with an EC50 value of 82 nM in cellular HCV assays[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TMC647055 相关抗体:
体内研究
(In Vivo)

TMC647055 (compound 18a) (2 mg/kg, iv.; 10mg/kg, po.) shows an acceptable PK profile, characterized by high oral bioavailability and high systemic exposure after single oral dosing of 10 mg/kg, combined with a moderate plasma clearanceand low volume of distribution[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[2]
Dosage: 2 mg/kg; 10mg/kg
Administration: 2 mg/kg, iv.; 10mg/kg, po.; singel
Result:
No. Cl (L/h/kg) Cmax(ng/mL) [Liver] (ng/mL) L/P F (%)
TMC647055 (compound 18a) 3.2 440 7800 46 ＞66
分子量

606.73

Formula

C32H38N4O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TMC647055 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TMC6470551204416-97-6TMC 647055TMC-647055HCVHepatitis C virusHepatitis C virus (HCV)HCV replicationmacrocycleratsInhibitorinhibitorinhibit

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产品名称：
TMC647055
目录号：
HY-15591
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