2. Apoptosis Vitamin D Related/Nuclear Receptor
  3. Apoptosis Androgen Receptor
  4. Torulene

Torulene (Torulin) 是一种具有口服活性和抗癌活性的类胡萝卜素。Torulene 可通过线粒体途径和下调表达雄激素受体 (androgen receptor) 的表达抑制细胞增值，诱导肿瘤细胞凋亡 (apoptosis)。Torulene 可用于前列腺癌的研究。

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Torulene Chemical Structure

Torulene Chemical Structure

CAS No. : 547-23-9

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Torulene 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Torulene (Torulin) is an orally active carotenoid with anti-cancer activity. Torulene inhibits proliferation and induces apoptosis of tumor cells via a mitochondrial signal pathway and the down-regulation of androgen receptor (AR) expression. Torulene can be used for the study of prostate cancer[1][2].

体外研究
(In Vitro)

Torulene (0-40 μM, 24 h) 剂量依赖性抑制 LNCaP 和 PC-3 细胞增值[2]。
Torulene (30 μM, 12, 24 and 48 h) 时间依赖性的引起了 LNCaP 和 PC-3 细胞凋亡且对雄激素敏感的 LNCaP 细胞诱导凋亡效果更显著[2]。
Torulene (10-40 μM, 24 h) 在 LNCaP 和 PC-3 细胞内降低了线粒体膜电位 (MMP) 和 Bax 表达，并导致细胞内钙离子浓度和 Bcl-2 表达升高[2]。
Torulene (10-30 μM, 24 h) 以剂量依赖的方式显著降低了 LNCaP 细胞中 AR 和 PSA 蛋白及 mRNA 的表达量[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Torulene 相关抗体:

Cell Viability Assay[2]

Cell Line: LNCaP and PC-3 cells
Concentration: 0, 10, 20, 30, 40, 50 μM
Incubation Time: 24 h
Result: Decreased cell viability approx. 50% on androgen-insensitive PC-3 cells.
Decreased cell viability approx. 15% on androgen-sensitive LNCaP cells.

RT-PCR[2]

Cell Line: LNCaP and PC-3 cells
Concentration: 10, 20 and 30 μM
Incubation Time: 24 h
Result: Decreased mRNA expression of Bcl-2 was from 1.00 to 0.94 (LNCap) and 0.59 (PC-3)-fold.
Increased expression of Bax from 1.00 to 2.29 (LNCap)- and 3.08 (PC-3)-fold.
体内研究
(In Vivo)

Torulene (9 and 18 mg/kg, p.o., 持续2 周) 显著抑制了荷瘤裸鼠体内前列腺肿瘤的生长，并且很可能与肿瘤细胞的凋亡有关[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PC-3 xenograft prostate tumors model established in six-week-old BALB/c male nude mice[1]
Dosage: 9 and 18 mg/kg
Administration: Oral administration (p.o.), for 2 weeks
Result: Lowered the mean number of tumors from 248.13 to 50.83.
Showed tumor degeneration, apoptosis and necrosis presented.
Decreased the expression of Bcl-2 and Increased the expression of Bax.
Increased the mRNA expressions of caspase-3, 8 and 9 in tumor tissues.
分子量

534.86

Formula

C40H54
CAS 号
结构分类
初始来源

Ramalina usnea thalli
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Torulene 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Torulene547-23-9TorulinApoptosisAndrogen ReceptorTorularhodinChemopreventionPC-3 xenograft prostate tumorsInhibitorinhibitorinhibit

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