1. PROTAC
  2. PROTAC Linker
  3. Tos-PEG4-THP

Tos-PEG4-THP 

目录号: HY-130819
产品使用指南

Tos-PEG4-THP 是一种 PROTAC 连接桥,属于 PEG 类。Tetraethylene glycol 可用于合成 PROTAC K-Ras Degrader-1 (HY-129523)。

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Tos-PEG4-THP Chemical Structure

Tos-PEG4-THP Chemical Structure

CAS No. : 86259-89-4

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500 mg ¥3500 In-stock
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Description

Tos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Molecular Weight

432.53

Formula

C₂₀H₃₂O₈S

CAS No.

86259-89-4

SMILES

O=S(C1=CC=C(C)C=C1)(OCCOCCOCCOCCOC2CCCCO2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Tos-PEG4-THPPROTAC LinkerPEGPROTAClinkerE3ubiquitinligaseproteinInhibitorinhibitorinhibit

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产品名称:
Tos-PEG4-THP
目录号:
HY-130819
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