2. PROTAC Metabolic Enzyme/Protease Stem Cell/Wnt Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Immunology/Inflammation
  3. PROTACs Phosphatase JAK IFNAR MHC
  4. TP1L

TP1L 是一种强效、选择性的 T 细胞蛋白酪氨酸磷酸酶 (TC-PTP) PROTAC 降解剂，DC50 值为 35.8 nM。TP1L 能提高 TC-PTP 底物的磷酸化水平，包括 pSTAT1 和 pJAK1。TP1L 选择性地增强 IFN-γ 信号传导并增加 MHC-I 的表达。TP1L 通过增加 LCK 的磷酸化激活 TCR 信号传导。TP1L 通过激活 CAR-T 细胞增强 CAR-T 细胞介导的肿瘤杀伤效能。TP1L 可用于癌症研究。(粉色：TC-PTP 配体：(HY-138964)，蓝色：E3 连接酶 CRBN 配体 (HY-A0003)，黑色：连接子：(HY-140002)。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

TP1L

TP1L Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

TP1L 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

查看 MHC 亚型特异性产品:

查看所有亚型
MHC I MHC II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TP1L is a potent and selective T-cell protein tyrosine phosphatase (TC-PTP) PROTAC degrader, with a DC50 value of 35.8 nM. TP1L elevates the phosphorylation level of TC-PTP substrates including pSTAT1 and pJAK1. TP1L selectively enhances IFN-γ signaling and increases MHC-I expression. TP1L activates TCR signaling through increases phosphorylation of LCK. TP1L enhances CAR-T cell mediated tumor killing efficacy through activation of the CAR-T cells. TP1L can be used for the study of cancer. (Pink: TC-PTP ligand: (HY-138964), Blue: E3 ligase CRBN Ligand (HY-A0003), Black: Linker: (HY-140002))[1].

体外研究
(In Vitro)

TP1L (0.5-4000 nM, 3-24 h) 在 HEK293 细胞中通过泛素化-蛋白酶体途径选择性地降解 TC-PTP (DC50 = 35.8 nM)[1]。
TP1L (<10 μM) 即使在浓度高达 10 μM 时，对其他蛋白酪氨酸磷酸酶 (PTPs) 也没有显著的抑制作用。 TP1L (0.5-4000 nM, 3-24 h) 在 HEK293 细胞中选择性地增强 IFN-γ 信号传导并促进抗原呈递[1]。
TP1L (62.5-1000 nM, 16 h) 在 Jurkat T 细胞中提高 pLCK 水平，并在 KB 肿瘤/CAR-T 细胞共培养系统中增强 CAR-T 细胞的杀伤效率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TP1L 相关抗体:

Western Blot Analysis[1]

Cell Line: HEK293 cells and Jurkat T-cells
Concentration: 0.5, 3.9, 7.8, 15.6, 31.2, 62.5, 125, 250, 500, 1000, 2000, 4000 nM
Incubation Time: 3, 6, 16, 24 h
Result: Degradated TC-PTP with a DC50 of 35.8 nM in HEK293 cells after 16 hours of treatment.
Showed no signicantly altered on the level of PTP1Bat up to 4 mM concentration.
Degradated TC-PTP completly within 6 hours.
Did not decrease during the entire period of TP1L treatment.
Enhanced the levels of pJAK1 and pSTAT1.
Did not affected the phosphorylation level of JAK2, which is a substrate of PTP1B.
Degraded TC-PTP and promoted phosphorylation of LCK in Jurkat T-cells.
分子量

1255.34

Formula

C64H81F2N8O14P
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TP1L 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TP1LPROTACsPhosphataseJAKIFNARMHCJanus kinaseInterferon-α/β receptorInterferon-alpha/beta receptor Major Histocompatibility ComplexTC-PTPSTAT1JAK1IFN-γ signalingCAR-T cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
TP1L
目录号：
HY-160151
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z