1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. TC-PTP-IN-1

TC-PTP-IN-1 (compound 8) 是一种有效的 TC-PTP 抑制剂,IC50 值为 9.2 nM,其对 TC-PTP 和 PTP1B 的 Ki 值分别为 4.3 nM 和 34 nM。TC-PTP-IN-1 可增加 pSre416 的蛋白表达。TC-PTP-IN-1 (compound 3) 是 TP1L (HY-160151) 的 TC-PTP 配体。

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TC-PTP-IN-1

TC-PTP-IN-1 Chemical Structure

CAS No. : 1187396-28-6

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TC-PTP-IN-1 (compound 8) is a potent TC-PTP inhibitor with an IC50 value of 9.2 nM, Ki values of 4.3, 34 nM for TC-PTP, PTP1B, respectively. TC-PTP-IN-1 increases the protein expression of pSre416[1]. TC-PTP-IN-1 (compound 3) is the TC-PTP Ligand of TP1L (HY-160151)[2].

体外研究
(In Vitro)

TC-PTP-IN-1 (compound 8) (5-50 nM; 2 h) 以剂量依赖性方式增加 pSre416 的蛋白表达[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: PTP1B−/− mouse embryo fibroblast cells
Concentration: 5, 10, 20, 50 nM
Incubation Time: 2 h
Result: Increased the expression of pSre416 in a dose-dependent manner but shows no increases in pSrc527.
分子量

897.98

Formula

C46H62F2N5O9P

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
TC-PTP-IN-1
目录号:
HY-138964
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