2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. TRPC antagonist 1

TRPC antagonist 1 (compound 15g) 是一种有效的 TRP 通道 (TRPC) 拮抗剂，对 TRPC3、TRPC4、TRPC5、TPRC6 和 TRPC7 的 IC50 值分别为 2.4 μM、12.2 μM、7.6 μM、2.9 μM 和 3.4 μM。TRPC antagonist 1 在体外针对 U87 细胞系表现出显着的抗胶质母细胞瘤功效。

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TRPC antagonist 1

TRPC antagonist 1 Chemical Structure

CAS No. : 3027139-12-1

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TRPC antagonist 1 相关抗体

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查看 TRP Channel 亚型特异性产品:

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TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TRPC antagonist 1 (compound 15g) is a potent TRP channel (TRPC) antagonist with IC50s of 2.4 μM, 12.2 μM, 7.6 μM, 2.9 μM, and 3.4 μM for TRPC3, TRPC4, TRPC5, TPRC6, and TRPC7, respectively. TRPC antagonist 1 displays noteworthy anti-glioblastoma efficacy in vitro against U87 cell lines[1].

IC50 & Target[1]

TRPC3

2.4 μM (IC50)

TRPC4

12.2 μM (IC50)

TRPC5

7.6 μM (IC50)

TRPC6

2.9 μM (IC50)

TRPC7

3.4 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
21.1 μM
Compound: 15g
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38185057]
HCT-116 IC50
9.8 μM
Compound: 15g
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38185057]
LNCaP IC50
8.3 μM
Compound: 15g
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38185057]
MKN-45 IC50
11 μM
Compound: 15g
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38185057]
U-87MG ATCC IC50
5.7 μM
Compound: 15g
Antiproliferative activity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38185057]
分子量

418.51

Formula

C23H22N4O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TRPC antagonist 1 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRPC antagonist 13027139-12-1TRPC antagonist1TRPC antagonist-1TRP ChannelTransient receptor potential channelsTRPC antagonistanti-glioblastoma agentTRPC3TRPC4TRPC5TPRC6and TRPC7Inhibitorinhibitorinhibit

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TRPC antagonist 1
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HY-162090
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