2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Microtubule/Tubulin Apoptosis Reactive Oxygen Species (ROS)
  4. Tubulin/CDC5L-IN-1

Tubulin/CDC5L-IN-1 是一种 Tubulin/CDC5L 双重抑制剂。Tubulin/CDC5L-IN-1 靶向 CDCL5，其 KD 值为 103.7 μM。Tubulin/CDC5L-IN-1 能够抑制多种癌细胞的增殖，并诱导 G2/M 期阻滞。Tubulin/CDC5L-IN-1 可诱导细胞凋亡 (apoptosis) 和 活性氧 (ROS) 产生。Tubulin/CDC5L-IN-1 具有抗血管生成作用。Tubulin/CDC5L-IN-1 可用于癌症研究，如结肠癌。

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Tubulin/CDC5L-IN-1

Tubulin/CDC5L-IN-1 Chemical Structure

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Tubulin/CDC5L-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin/CDC5L-IN-1 is a Tubulin/CDC5L dual inhibitor. Tubulin/CDC5L-IN-1 targets to CDCL5 with a KD of 103.7 μM. Tubulin/CDC5L-IN-1 can inhibit multiple cancer cell proliferation and induce G2/M phase arrest. Tubulin/CDC5L-IN-1 induce cell apoptosis and ROS production. Tubulin/CDC5L-IN-1 exhibits antiangiogenic effects. Tubulin/CDC5L-IN-1 can be used for the research of cancer, such as colon carcinoma[1].

体外研究
(In Vitro)

Tubulin/CDC5L-IN-1 (Compound 11i) (48 h) 可抑制 HeLa、HCT 116、A2780 和 A549 细胞的增殖，其 IC50 值分别为 0.046、0.035、0.096 和 0.112 μM[1]。
Tubulin/CDC5L-IN-1 在耐药性癌细胞中显示出抗增殖功效，其 IC50 值范围为 0.089-0.172 μM[1]。
Tubulin/CDC5L-IN-1 (1-100 μM, 0-30 mins) 可抑制微管组装，其 IC50 值为 28.8 μM[1]。
Tubulin/CDC5L-IN-1 (0.125-0.05 μM, 24 h) 可抑制 HeLa 细胞和 HCT 116 细胞的集落形成[1]。
Tubulin/CDC5L-IN-1 (0.125-0.1 μM, 12 h) 可诱导 HCT 116 细胞发生 G2/M 期阻滞[1]。
Tubulin/CDC5L-IN-1 (0.05-0.2 μM, 24 h) 可诱导 HCT 116 细胞凋亡并产生活性氧 (ROS)[1]。
Tubulin/CDC5L-IN-1 (0.05-0.2 μM, 4 h) 可抑制人脐静脉内皮细胞 (HUVECs) 中毛细血管样结构的形成[1]。
Tubulin/CDC5L-IN-1 (5 μM) 可抑制 DNA 依赖性蛋白激酶和细胞分裂周期 7[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin/CDC5L-IN-1 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HCT 116 cells
Concentration: 0.125, 0.05 and 0.1 μM
Incubation Time: 12 h
Result: Increased cells in the G2/M phase.
Increased the phosphorylation level of histone H3 (PHH3) at Ser10.
体内研究
(In Vivo)

Tubulin/CDC5L-IN-1 (Compound 11i) (7.5-20 mg/kg，腹腔注射，每 2 天一次) 在 HCT116 异种移植小鼠模型中可抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCT116 xenograft mice models[1]
Dosage: 7.5, 10 and 20 mg/kg
Administration: Intraperitoneally injection, every 2 days
Result: Reduced tumor weight and volume.
Had no body weight loss.
Decreased Ki67-positive cells and reduced tumor microvessel density.
Had no histopathological changes in the heart, liver, spleen, lungs, or kidneys.
分子量

580.59

Formula

C28H32N6O8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin/CDC5L-IN-1 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin/CDC5L-IN-1Microtubule/TubulinApoptosisReactive Oxygen Species (ROS)TubulinCDC5LROSColon carcinomaHeLaHCT 116A2780A549Inhibitorinhibitorinhibit

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