2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin inhibitor 35

Tubulin inhibitor 35 (compound 6b) 是拓扑异构酶 I (IC50=~50 μM) 和微管蛋白聚合 (IC50=5.69 μM) 的双重抑制剂。Tubulin inhibitor 35 抑制 MGC-803 和 RKO 细胞株的迁移和侵袭，并通过在 G2/M 期阻滞细胞周期诱导凋亡 (apoptosis)。Tubulin inhibitor 35 对胃肠道肿瘤有较强的抑制作用 (对 MGC-803 的 IC50=0.09 μM，对 RKO 的 IC50=0.2 μM)。

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Tubulin inhibitor 35

Tubulin inhibitor 35 Chemical Structure

CAS No. : 2247047-77-2

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规格 价格 是否有货 数量
1 mg ￥832
1 - 2 周
5 mg ￥1940
1 - 2 周
10 mg ￥2838
1 - 2 周
25 mg ￥4774
1 - 2 周
50 mg 询价 1 - 2 周
100 mg   询价  
200 mg   询价  

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Tubulin inhibitor 35 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin inhibitor 35 (compound 6b) is a dual inhibitor of topoisomerase I (IC50=~50 μM) and tubulin polymerization (IC50=5.69 μM). Tubulin inhibitor 35 inhibits migration and invasion of MGC-803 and RKO cell lines，and induces apoptosis via arresting cell cycle at G2/M phase. Tubulin inhibitor 35 exhibis potent efficacy in gastrointestinal tumor inhibiton (inhibits MGC-803 (IC50=0.09 μM) and RKO (IC50=0.2 μM) cell lines)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
GES1 IC50
0.13 μM
Compound: 6b
Antiproliferative activity against human GES1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human GES1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 37099835]
HGC-27 IC50
0.81 μM
Compound: 6b
Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 37099835]
LoVo IC50
0.23 μM
Compound: 6b
Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 37099835]
MGC-803 IC50
0.09 μM
Compound: 6b
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 37099835]
RKO IC50
0.2 μM
Compound: 6b
Antiproliferative activity against human RKO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human RKO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 37099835]
SGC-7901 IC50
0.09 μM
Compound: 6b
Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 37099835]
SW480 IC50
0.71 μM
Compound: 6b
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 37099835]
分子量

331.41

Formula

C21H21N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin inhibitor 35 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 352247047-77-2Tubulin inhibitor35Tubulin inhibitor-35Microtubule/TubulinApoptosisInhibitorinhibitorinhibit

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