2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin polymerization-IN-81

Tubulin inhibitor 51 是一种有选择性的 Tubulin 抑制剂，其 IC50 值为 5.41 μM。Tubulin inhibitor 51 具有显著的抗细胞增值活性、独特的活性氧介导的细胞凋亡机制以及强大的抗微管蛋白活性。Tubulin inhibitor 51 可用于抗肿瘤研究 。

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Tubulin polymerization-IN-81 Chemical Structure

Tubulin polymerization-IN-81 Chemical Structure

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Tubulin polymerization-IN-81 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin inhibitor 51 is a selective Tubulin inhibitor with an IC50 of 5.41 μM. Tubulin inhibitor 51 possesses a significant anti-proliferative activity, unique ROS-mediated apoptotic mechanism and potent anti-microtubule activity. Tubulin inhibitor 51 can be used in anti-tumor research[1].

体外研究
(In Vitro)

Tubulin inhibitor 51 (Compound 4a) (10 μM) 对 15 种癌细胞系表现出强大的活性，并且对 SF-539 和 CAKI-1 细胞具有致死性，其 GI 值分别为 112.22% 和 150.64%[1]。
Tubulin inhibitor 51 具有高活性和选择性，其 IC50值分别为 3.46、5.93 和 42.71 μM，分别针对 OVCAR-4、A549 和非肿瘤细胞 WI-38 时表现出不同的活性[1]。
Tubulin inhibitor 51 (6 μM, 20 min) 阻碍了 A549 细胞中微管的聚合，IC50值为 5.41 μM[1]。
Tubulin inhibitor 51 (5.93μM, 48 h) 通过在 A549 细胞中使细胞周期停滞在 G2/M 期（34.8%）来阻止癌细胞增殖[1]。
Tubulin inhibitor 51 (5.93μM, 48 h) 诱导了 85% 的 A549 细胞死亡，而这主要发生在 A549 细胞的早期阶段[1]。
Tubulin inhibitor 51 (5.93μM, 48 h) 在 A549 细胞中具备显著的活性氧生成水平，并使其增加了 2.4 倍[1]。
Tubulin inhibitor 51 (5.93μM, 48 h) 和对照物 CA-4，在 A549 细胞中显示出 56-67% 的 MMP 损失[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-81 相关抗体:

Cell Proliferation Assay[1]

Cell Line: OVCAR-4, A549, WI-38
leukemia (MOLT-4 and RPMI-8226), colon cancer (HCT-15), melanoma (LOX IMIV), renal cancer (CAKI-1), ovarian cancer (NCI/ADR-RES) and breast cancer (BT-549 and MDA-MB-468)
Concentration: 10 μM
Incubation Time: 48 h
Result: Exhibited potent activity against fifteen cancer cell lines, including (A549/ATCC, HOP-92, NCI-H226, SF-268, SNB-19, SNB-75, U251, SK-MEL-28, UACC-257, OVCAR-3, OVCAR-4, OVCAR-8, HS 578T) with growth inhibition range of 60.88 %-86.51 %.
Exhibited mean inhibition against all nine cancer cell lines of 41.03 % Showed the highest anti-proliferative activity against both cell lines with IC50 = 3.46 and 5.93 μM against OVCAR-4 and A549, respectively.
Showed weak activity towards non-tumor cells WI-38 with IC50 value 42.71 μM.
Demonstrated better safety to¬ wards WI-38 cells (IC50 = 42.71 μM) than CA-4, with a selectivity index (SI*) equal to 7.20.
分子量

497.50

Formula

C27H23N5O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-81 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-81Microtubule/TubulinApoptosisCA-4CBSIs TubulinCytotoxic activityROSInhibitorinhibitorinhibit

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