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UHMCP1 是 U2AF 同源基序 (UHM) 的化学探针,Kd 为 79 μM。UHMCP1 抑制 SF3b155/U2AF65 的相互作用,影响 RNA 剪接和细胞活力。UHMCP1 具有潜在的抗癌特性。

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UHMCP1 Chemical Structure

UHMCP1 Chemical Structure

CAS No. : 2103079-87-2

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Other Forms of UHMCP1:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UHMCP1 is a chemical probe of U2AF homology motifs (UHM) with a Kd of 79 μM. UHMCP1 prevents the SF3b155/U2AF65 interaction, impacts RNA splicing and cell viability. UHMCP1 has potential anticancer properties[1].

IC50 & Target

Kd: 79 µM (UHM domain)[1]

体外研究
(In Vitro)

UHMCP1 (25-400 μM) reduces the binding of purified U2AF65 to SF3b155 by 75%, exhibiting a simple, non-cooperative binding mode with Kd around 30 μM for U2AF65[1].
UHMCP1 (0-200 μM; 24 h) exhibits a certain effect on cell viability of HEK293[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HEK293 cells
Concentration: 0-100 µM
Incubation Time: 24 h
Result: Inhibited cell viability with an EC50 value of 140 µM.
分子量

297.44

Formula

C19H27N3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

UHMCP1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
UHMCP1
目录号:
HY-148384
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