2. GPCR/G Protein
  3. CRFR
  4. Urocortin III (human) TFA

Urocortin III (human) TFA 是一种促肾上腺皮质激素释放因子 (CRF) 相关肽。Urocortin III (human) TFA 优先结合并激活 CRF-R2，在中枢神经系统和外周组织中均有分布。Urocortin III (human) TFA 能强效结合 2 型 CRF 受体，特别是 mCRF2β (Ki = 13.5 nM) 和 rCRF2α (Ki = 21.7 nM)，而对 hCRF1 的亲和力极低 (Ki >100 nM)。Urocortin III (human) TFA 介导生长抑素依赖的 Insulin (human) (HY-P0035) 分泌的负反馈调控[1][2]。

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Custom Peptide Synthesis

Urocortin III (human) TFA

Urocortin III (human) TFA Chemical Structure

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规格 价格 是否有货 数量
500 μg ￥3866
In-stock
1 mg 询价 3 - 4 周
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Customer Review

Other Forms of Urocortin III (human) TFA:

Urocortin III (human) TFA 相关抗体

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CRFR1 CRFR2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Urocortin III (human) TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) TFA preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) TFA potently binds to type 2 CRF receptors, specifically mCRF2β (Ki = 13.5 nM) and rCRF2α (Ki = 21.7 nM), while demonstrating negligible affinity for hCRF1 (Ki >100 nM). Urocortin III (human) TFA mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion[1][2].

IC50 & Target[1]

mCRF2β

13.5 nM (Ki)

rCRF2α

21.7 nM (Ki)

体外研究
(In Vitro)

Urocortin III (human) (0.001-1000 nM，20 分钟) FTA 可诱导稳定表达鼠 CRF-R2 的 CHO 细胞内 cAMP 积累[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Urocortin III (human) TFA 相关抗体:
分子量

4137.87 (free base)

Formula

C185H307N53O50S2.xC2HF3O2
Sequence

Phe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Leu-Leu-Phe-Asn-Ile-Ala-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Gln-Ala-Ala-Ala-Asn-Ala-His-Leu-Met-Ala-Gln-Ile-NH2
Sequence Shortening

FTLSLDVPTNIMNLLFNIAKAKNLRAQAAANAHLMAQI-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Urocortin III (human) TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Urocortin III (human)CRFRCorticotropin-releasing Factor ReceptorCRHRcorticotropin-releasing factorcentral nervous systeminsulinperipheralsomatostatin-dependentInhibitorinhibitorinhibit

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目录号：
HY-P3019A
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