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VK3-OCH3 是一种有效的抗肿瘤剂。 VK3-OCH3 对神经母细胞瘤细胞系表现出细胞毒性，而对正常细胞系表现出低细胞毒性。VK3-OCH3 在 IMR-32 细胞中诱导 凋亡 和细胞周期停滞在 G2/M 期。VK3-OCH3 显示出抗肿瘤活性。

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VK3-OCH3 Chemical Structure

VK3-OCH3 Chemical Structure

CAS No. : 255906-59-3

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规格 价格 是否有货
10 mg ￥2286
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VK3-OCH3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VK3-OCH3 is a potent antitumor agent. VK3-OCH3 shows cytotoxicity for neuroblastoma cell lines and low cytotoxicity for normal cell lines. VK3-OCH3 induces apoptosis and cell cycle arrest at G2/M phase in IMR-32 cells. VK3-OCH3 shows antitumor activity[1].

体外研究
(In Vitro)

VK3-OCH3 (compound 5) shows cytotoxicity with IC50s of 2.43, 1.55, 10.69, 3.45, 26.24, 87.11 µM for IMR-32, LA-N-1, NB-39, SK-N-SH, HUVEC, HDF cells, respectively[1].
VK3-OCH3 (1, 3, 10 µM) induces apoptosis and cell cycle arrest at G2/M phase in IMR-32 cells[1].
VK3-OCH3 (0-48 h) increases the expression of HO-1 in 8~24 h, and Caveolin-1 in 48 h in IMR-32 and LA-N-1 cells[1].
VK3-OCH3 (0-48 h) increases the expression of phospho-p38-MAPK and decreases the expression of p21 and clusterin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VK3-OCH3 相关抗体:
分子量

262.32

Formula

C14H14O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VK3-OCH3 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VK3-OCH3255906-59-3OtherscytotoxicitIMR-32 cellapoptosisG2/M phaseHO-1Caveolin-1Inhibitorinhibitorinhibit

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