2. Others Neuronal Signaling GPCR/G Protein
  3. 5-HT Receptor Isotope-Labeled Compounds Serotonin Transporter
  4. Vortioxetine-d4

Vortioxetine-d4  (Synonyms: Lu AA 21004-d4)

目录号: HY-15414S2
产品使用指南 技术支持

Vortioxetine-d4 (Lu AA 21004-d4) 是一种 Vortioxetine (HY-15414) 的氘代物。Vortioxetine 是 5-HT3A，5-HT7 受体的拮抗剂 (Ki: 3.7 nM，19 nM) 和 5-羟色胺转运体 (SERT) 的抑制剂 (Ki: 1.6 nM)，还是 5-HT1A 的激动剂和 5-HT1B 的部分激动剂 (Ki: 15 nM，33 nM)。

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Vortioxetine-d<sub>4</sub>

Vortioxetine-d4 Chemical Structure

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Vortioxetine-d4 相关抗体

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vortioxetine-d4 (Lu AA 21004-d4) is the deuterium labeled Vortioxetine (HY-15414). Vortioxetine is an antagonist of 5-HT3A and 5-HT7 receptors (Ki: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (Ki: 1.6 nM), as well as a 5-HT1A agonist and a partial agonist of 5-HT1B (Ki: 15 nM, 33 nM)[1][2].

IC50 & Target

5-HT1A Receptor

 

5-HT1B Receptor

 

5-HT3A Receptor

 

5-HT7 Receptor

 

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vortioxetine-d4 相关抗体:
分子量

302.47

Formula

C18H18D4N2S
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Vortioxetine-d4 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vortioxetine-d4Lu AA 21004-d45-HT ReceptorIsotope-Labeled CompoundsSerotonin TransporterSerotonin Receptor5-hydroxytryptamine Receptor5-HTTSERTSLC6A4Inhibitorinhibitorinhibit

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