2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. α-Conotoxin MII

α-Conotoxin MII  (Synonyms: α-CTxMII)

目录号: HY-P1365 纯度: 98.53%
COA 产品使用指南

摩尔计算器

α-Conotoxin MII (α-CTxMII) 是可从海螺 Conus magus 中分离得到，有效抑制 nAChR 受体的 α3β2 亚基，其 IC50 值为 0.5 nM。α-Conotoxin MII (α-CTxMII) 可有效抑制 β3-containing 神经尼古丁受体。

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Custom Peptide Synthesis

α-Conotoxin MII Chemical Structure

α-Conotoxin MII Chemical Structure

CAS No. : 175735-93-0

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1 mg ￥8200
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Other Forms of α-Conotoxin MII:

α-Conotoxin MII 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. α-Conotoxin MII (α-CTxMII) potently blocks β3-containing neuronal nicotinic receptors [1][2][3].

IC50 & Target

IC50: 0.5 nM (α3β2)[1].
体外研究
(In Vitro)

α-Conotoxin MII (0.5-3.5 nM) blocks ACh responses in oocytes expressing α3β2 nicotinic acetylcholine receptors[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

α-Conotoxin MII 相关抗体:
分子量

1710.94

Formula

C67H103N23O22S4
CAS 号
性状

固体

颜色

White to off-white

Sequence

Gly-Cys-Cys-Ser-Asn-Pro-Val-Cys-His-Leu-Glu-His-Ser-Asn-Leu-Cys-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16)
Sequence Shortening

GCCSNPVCHLEHSNLC-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

纯度 & 产品资料
参考文献

α-Conotoxin MII 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Conotoxin MII175735-93-0α-CTxMIInAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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目录号：
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