2. Anti-infection Immunology/Inflammation Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Fungal COX PPAR
  4. β-Amyrone

β-Amyrone  (Synonyms: β-Amyron)

目录号: HY-N2925 纯度: 99.63%
COA 产品使用指南

摩尔计算器

β-Amyrone (β-Amyron) 是一种三萜类化合物，通过抑制 COX-2 的表达而发挥抗炎活性。β-Amyrone 具有抗真菌活性，及针对 Chikungunya 病毒的抗病毒活性。β-Amyrone 还可抑制 α-葡萄糖苷酶 (α-glucosidase ) 和乙酰胆碱酯酶 (AChE) 的活性。β-Amyrone 可用于炎症，感染，肥胖等疾病的研究。

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β-Amyrone Chemical Structure

β-Amyrone Chemical Structure

CAS No. : 638-97-1

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1 mg ￥1500
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5 mg ￥4200
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10 mg ￥6200
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β-Amyrone 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

查看 PPAR 亚型特异性产品:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity[1][2][3][4].

IC50 & Target[1]

COX-2

 

体外研究
(In Vitro)

β-Amyrone (1.25-10 μg/mL, 24 h) inhibits on NO∙ production in LPS-stimulated J774 cells, with an IC50 value of 4.61 μg/mL, and has no obvious effect on cell viability[1].
β-Amyrone (10 μg/mL, 24 h) inhibits IL-6, IL-10 levels, and COX-2 expression in LPS-stimulated J774 cells[1].
β-Amyrone (0-235 μM, 7days) has antiviral activity in Vero cells against Chikungunya virus (CHIKV), with EC50 value of 86 uM[2].
β-Amyrone inhibits α-glucosidase, acetylcholinesterase (AChE) and fungal activity with IC50 values of 25 μM, 23 μM and 8 μg/mL, respectively[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

β-Amyrone 相关抗体:

Western Blot Analysis[1]

Cell Line: LPS (1 μg/mL)-stimulated J774 cells
Concentration: 2.5, 5, 10 μg/mL
Incubation Time: 24 h
Result: Inhibited COX-2 expression in a concentration-dependent manner (approximately 90% reduction at 5 or 10 μg/ mL).
体内研究
(In Vivo)

β-Amyrone (local administration on ear, 0.1-0.6 mg/kg, a single dose) inhibits ear edema formation in phenol-induced edema mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ear phenol-induced edema in Balb C mice[1]
Dosage: 0.1, 0.3, 0.6 mg/kg, a single dose
Administration: Local administration (20 𝜇L solution) on ear
Result: Inhibited ear edema formation in a dose-related manner (47% inhibition at the dose of 0.6mg/kg).
分子量

424.70

Formula

C30H48O
CAS 号
性状

固体

颜色

White to off-white

中文名称

β-香树脂酮
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 99.63%

COA (176 KB) HNMR (227 KB) RP-HPLC (212 KB)

产品使用指南 (1538 KB)
参考文献

β-Amyrone 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Amyrone638-97-1β-Amyronβ-香树脂酮FungalCOXPPARCyclooxygenasePeroxisome proliferator-activated receptorsAnti-inflammatoryinflammationantifungalCOX-2CHIKVobesityPI3K-AktAChEinfectionInhibitorinhibitorinhibit

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