2. Protein Tyrosine Kinase/RTK Apoptosis JAK/STAT Signaling PI3K/Akt/mTOR
  3. VEGFR Apoptosis EGFR mTOR
  4. 4-TCPA

4-TCPA 是一种强效的 VEGFR2 抑制剂。4-TCPA诱导凋亡 (apoptosis) 和细胞周期阻滞，可能是通过抑制 VEGFR2 和 EGFR 信号传导，并对 mTOR 途径产生额外影响。4-TCPA 能抑制多种癌细胞系的活力和增殖。4-TCPA 可用于诸如肺癌、乳腺癌和白血病等癌症的研究。

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4-TCPA

4-TCPA Chemical Structure

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4-TCPA 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 mTOR 亚型特异性产品:

查看所有亚型
mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4-TCPA is a potent VEGFR2 inhibitor. 4-TCPA induces apoptosis and cell cycle arrest, likely through inhibition of VEGFR2 and EGFR signaling with additional effects on the mTOR pathway. 4-TCPA can inhibit the vitality and proliferation of various cancer cell lines. 4-TCPA can be used for the study of cancers such as lung cancer, breast cancer and leukemia[1].

IC50 & Target[1]

VEGFR2

 

mTOR

 

体外研究
(In Vitro)

4-TCPA (0-200 μM, 72 h) 4-TCPA 对 A549 细胞的 IC50 值为 35.70 μM，对 MCF7 细胞为 19.50 μM，对 K562 细胞为 5.95 μM，对 HFF2 细胞为 135.2 μM[1].
4-TCPA (5.95-35.70 μM, 72 h) 以不同的敏感性激活线粒体途径，在 K562、MCF7 和 A549 细胞系中引起细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4-TCPA 相关抗体:

Cell Proliferation Assay[1]

Cell Line: K562, MCF7, A549 and HFF2 cells
Concentration: 5, 10, 15, 20, 30, 40, 50, 60, 70, 80, 90, 100, 150, 200 μM
Incubation Time: 72 h
Result: Demonstrated a dose- and time-dependent decrease in the viability and proliferation of cell lines.
Exhibited nearly twofold more activity in producing cytotoxic effects on the cancer cell line.
Was somewhat hazardous to the regular HFF2 cell line.

Apoptosis Analysis[1]

Cell Line: K562, MCF7, A549 cells
Concentration: 5.95, 19.50, 35.70 μM
Incubation Time: 72 h
Result: The early and late apoptosis in all cell lines increased significantly with time.
Observed more than 40% of the treated cells underwent apoptosis.
Increased the activity of caspase 3/7 in a time-dependent manner.

RT-PCR[1]

Cell Line: K562, MCF7, A549 and HFF2 cells
Concentration: 5, 10, 15, 20, 30, 40, 50, 60, 70, 80, 90, 100, 150, 200 μM
Incubation Time: 72 h
Result: Decreased the levels of EGFR, VEGFR2 and mTOR in A549.
Decreased the levels of EGFR, VEGFR2, mTOR, MAPK-1 and PIK3CA in MCF7.
Decreased the levels of EGFR, VEGFR2, mTOR, MAPK-1 and Akt in K562.
分子量

541.99

Formula

C25H28ClN7O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4-TCPA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-TCPAVEGFRApoptosisEGFRmTORVascular endothelial growth factor receptorEpidermal growth factor receptorErbB-1HER1Mammalian target of RapamycinQuinazolineCancer cellVEGFR2Inhibitorinhibitorinhibit

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