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AVE5688 

目录号: HY-100320
产品使用指南

AVE5688 是糖原磷酸化酶 (glycogen phosphorylase (GP)) 抑制剂,抑制兔肌肉糖原磷酸化酶 rmGPb 和 rmGPa 的活性,IC50 值分别为 430 nM 和 915 nM,Kd 值分别为 170 nM 和 530 nM;AVE5688 可用于二型糖尿病的研究。

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AVE5688 Chemical Structure

AVE5688 Chemical Structure

CAS No. : 613260-13-2

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  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

IC50 & Target

IC50: 430 nM (rmGPb), 915 nM (rmGPa)[1]
Kd: 170 nM (rmGPb), 530 nM (rmGPa)[1]

体外研究
(In Vitro)

AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

438.69

Formula

C16H8ClF5N2O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
Kinase Assay
[1]

Glycogen phosphorylase activity is measured in the physiological direction of glycogen breakdown. rmGP is used for the kinetic characterization of the inhibitors (AVE5688). To routinely check the phosphorylation grade of enzyme batches, activity is measured in the direction of glycogen synthesis; the phosphorylation grade is estimated from the ratio of the activity in the presence of 0.5 mM caffeine to the activity in the presence of 2 mM AMP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
AVE5688
目录号:
HY-100320
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