1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. iGluR
  3. CNS-5161 hydrochloride

CNS-5161 hydrochloride  (Synonyms: CNS 5161A)

目录号: HY-101809
产品使用指南

CNS-5161 hydrochloride 是一种新型 NMDA 离子通道拮抗剂,与 NMDA 受体/离子通道位点相互作用,产生对谷氨酸作用的非竞争性阻断。

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CNS-5161 hydrochloride Chemical Structure

CNS-5161 hydrochloride Chemical Structure

CAS No. : 160756-38-7

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Other Forms of CNS-5161 hydrochloride:

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CNS-5161 hydrochloride is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.

IC50 & Target

NMDA receptor/ion channel[1]

体外研究
(In Vitro)

CNS-5161 (CNS 5161) is a novel and selective noncompetitive antagonist of the NMDA subset of glutamate receptors in the mammalian brain. CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [3H] MK-801 binding with a Ki of 1.8 nM in synaptosomal membrane preparations from rat brain[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (CNS 5161) protects against the necrotic effects of exogenous N-methyl-D-aspartate with an ED80 of 4 mg/kg by the intraperitoneal (i.p.) route. CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p., and has a neuroprotective effect following hypoxix/ischaemic brain injury in neonatal rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

388.38

Formula

C16H19Cl2N3S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

CNS-5161 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
CNS-5161 hydrochloride
目录号:
HY-101809
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