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Canthaxanthin  (Synonyms: 斑蝥黄; E 161g; all-trans-Canthaxanthin)

目录号: HY-B1960 纯度: ≥98.0%
COA 产品使用指南

Canthaxanthin是具有多种生物活性的红橙色类胡萝卜素,如抗氧化,抗肿瘤活性。

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Canthaxanthin Chemical Structure

Canthaxanthin Chemical Structure

CAS No. : 514-78-3

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Top Publications Citing Use of Products
  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties.

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

LDL 的 Canthaxanthin 富集具有保护胆固醇免于氧化的潜力。除了其自由基清除和抗氧化特性 (例如,过氧化氢酶和超氧化物歧化酶的诱导) 外,Canthaxanthin 还具有免疫调节活性 (例如增强免疫感受态细胞的增殖和功能) 并在缝隙连接通讯中发挥重要作用 (例如诱导跨膜蛋白连接蛋白)[1]。在 0.1 到 1 x 1000 μM 的浓度下,Canthaxanthin 显著减少肿瘤细胞的总数。在孵育 72 小时和 96 小时后,在 Canthaxanthin 浓度为 1000 时观察到最大的抑制作用[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Canthaxanthin 改变组织对抗氧化应激的保护能力。Canthaxanthin 以 14 μg/kg 的剂量处理 15 天导致类胡萝卜素在肝脏中的掺入,在肝脏中含量最高,达到 0.52 ± 0.05 nmol/g。Canthaxanthin 处理小鼠的谷胱甘肽过氧化物酶活性比对照组低 35%,过氧化氢酶 (59%) 和锰超氧化物歧化酶 (28%) 活性高于对照组[3]。Canthaxanthin 抑制小鼠乳腺肿瘤的生长,其抗肿瘤活性还受补充剂量的影响[4]。通过一种不涉及维生素 A 原活性的机制,在摄入致癌物之前 3 周在饮食中补充 Canthaxanthin 可使乳腺癌的发病率降低 65%[5]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

564.84

Formula

C40H52O2

CAS 号
性状

固体

颜色

Reddish brown to black

中文名称

角黄素;斑蝥黄质;斑蝥黄;裸藻酮

结构分类
初始来源

extremely halophilic bacteria

运输条件

Shipping with dry ice.

储存方式

-20°C, protect from light, stored under nitrogen

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

纯度 & 产品资料

纯度: ≥98.0%

参考文献
Animal Administration
[3]

Mice: Female 6-wk-old Balb/c mice are randomly divided into two groups (n = 10/group). The control group receives olive oil alone (vehicle) and the canthaxanthin-treated group receives canthaxanthin at a dose of 14 μg/kg body weight per day. At the end of the treatment, mice are killed by cervical dislocation and liver is excised, frozen in liquid nitrogen and stored at −80°C[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目录号:
HY-B1960
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