2. Anti-infection
  3. HBV
  4. Entecavir

Entecavir  (Synonyms: 恩替卡韦; BMS200475; SQ34676)

目录号: HY-13623 纯度: 98.58%
COA 产品使用指南

摩尔计算器

Entecavir（SQ 34676; BMS 200475）是有选择且有效地HBV抑制剂，在HepG2细胞中的EC50值为3.75 nM。

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Entecavir Chemical Structure

Entecavir Chemical Structure

CAS No. : 142217-69-4

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规格 价格 是否有货 数量
1 mg ￥220
In-stock
5 mg ￥550
In-stock
10 mg ￥990
In-stock
25 mg ￥1480
In-stock
50 mg ￥2090
In-stock
100 mg ￥3700
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Other Forms of Entecavir:

Entecavir 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.

IC50 & Target

EC50: 3.75 nM (anti-HBV, HepG2 cell)[2]
体外研究
(In Vitro)

BMS-200475 has a EC50 of 3.75 nM against HBV. It is incorporated into the protein primer of HBV and subsequently inhibits the priming step of the reverse transcriptase. The antiviral activity of BMS-200475 is significantly less against the other RNA and DNA viruses[1]. Entecavir is more readily phosphorylated to its active metabolites than other deoxyguanosine analogs (penciclovir, ganciclovir, lobucavir, and aciclovir) or lamivudine. The intracellular half-life of entecavir is 15 h[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Entecavir 相关抗体:
体内研究
(In Vivo)

Daily oral treatment with BMS-200475 at doses ranging from 0.02 to 0.5 mg/kg of body weight for 1 to 3 months effectively reduces the level of woodchuck hepatitis virus (WHV) viremia in chronically infected woodchucks[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

277.28

Formula

C12H15N5O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

恩替卡韦
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 44 mg/mL (158.68 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.6065 mL 18.0323 mL 36.0646 mL
5 mM 0.7213 mL 3.6065 mL 7.2129 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.88%

COA (266 KB) HNMR (181 KB) LCMS (455 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

BMS 200475 is prepared in phosphate-buffered saline (PBS) and diluted with appropriate medium containing 2% fetal bovine serum. HepG2 2.2.15 cells are plated at a density of 5×105 cells per well on 12-well Biocoat collagen-coated plates and are maintained in a confluent state for 2 to 3 days before being overlaid with 1 mL of medium spiked with BMS 200475. Quantification of HBV was performed on day 10[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Entecavir 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6065 mL 18.0323 mL 36.0646 mL 90.1616 mL
5 mM 0.7213 mL 3.6065 mL 7.2129 mL 18.0323 mL
10 mM 0.3606 mL 1.8032 mL 3.6065 mL 9.0162 mL
15 mM 0.2404 mL 1.2022 mL 2.4043 mL 6.0108 mL
20 mM 0.1803 mL 0.9016 mL 1.8032 mL 4.5081 mL
25 mM 0.1443 mL 0.7213 mL 1.4426 mL 3.6065 mL
30 mM 0.1202 mL 0.6011 mL 1.2022 mL 3.0054 mL
40 mM 0.0902 mL 0.4508 mL 0.9016 mL 2.2540 mL
50 mM 0.0721 mL 0.3606 mL 0.7213 mL 1.8032 mL
60 mM 0.0601 mL 0.3005 mL 0.6011 mL 1.5027 mL
80 mM 0.0451 mL 0.2254 mL 0.4508 mL 1.1270 mL
100 mM 0.0361 mL 0.1803 mL 0.3606 mL 0.9016 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Entecavir142217-69-4BMS200475 SQ34676恩替卡韦BMS 200475BMS-200475SQ34676SQ 34676SQ-34676HBVHepatitis B virusInhibitorinhibitorinhibit

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