2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. G-744

G-744是有效，选择性的、口服有效的 Btk 抑制剂，IC50 值为2 nM。G-744代谢稳定，耐受性好，对关节炎有效。

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G-744 Chemical Structure

G-744 Chemical Structure

CAS No. : 1346669-54-2

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G-744 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

G-744 is a highly potent, selective and orally active Btk inhibitor with an IC50 of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis[1].

IC50 & Target

IC50: 2 nM (Btk), 64 nM (CD86)[1].
体内研究
(In Vivo)

G-744 (6.25/12.25/25 mg/kg, p.o., b.i.d., daily) protects Lewis rats from collagen-induced arthritis dose-dependently[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Lewis rat based CIA models[1].
Dosage: 6.25, 12.25, 25 mg/kg.
Administration: Orally, b.i.d., daily for 17 days.
Result: All three doses resulted in a significant dose-dependent inhibition of ankle thickness between day 10 and day 17 (onset of increase in ankle diameter on day 9).
分子量

527.64

Formula

C29H29N5O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

G-744 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G-7441346669-54-2G744G 744BtkBruton tyrosine kinaseInhibitorinhibitorinhibit

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产品名称：
G-744
目录号：
HY-102036
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