2. Metabolic Enzyme/Protease Apoptosis
  3. Proteasome Apoptosis
  4. K-7174 dihydrochloride

K-7174 dihydrochloride 

目录号: HY-12743A 纯度: 98.02%
COA 产品使用指南

摩尔计算器

K-7174 dihydrochloride 是具有口服活性的 proteasome 和 GATA 的抑制剂。K-7174 dihydrochloride 抑制细胞黏附。K-7174 dihydrochloride 诱导细胞凋亡。K-7174 dihydrochloride 具有抗肿瘤活性，可用于癌症的研究。

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K-7174 dihydrochloride Chemical Structure

K-7174 dihydrochloride Chemical Structure

CAS No. : 191089-60-8

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥1553
In-stock
1 mg ￥500
In-stock
5 mg ￥1100
In-stock
10 mg ￥1650
In-stock
25 mg ￥2600
In-stock
50 mg ￥4200
In-stock
100 mg ￥6500
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Other Forms of K-7174 dihydrochloride:

K-7174 dihydrochloride 相关抗体

Top Publications Citing Use of Products

    K-7174 dihydrochloride purchased from MCE. Usage Cited in: Brain Res. 2022.

    K-7174 (30 mg/kg; i.p.; 3 times a week for 6 weeks) improves lupus-like symptoms in MRL/lpr mice. The deposition of IgG and C3 in the kidneys of mice in the MRL/lpr group is significantly higher than that in the control group, but K-7174 can significantly inhibit this deposition.

    K-7174 dihydrochloride purchased from MCE. Usage Cited in: Brain Res. 2022.

    K-7174 significantly increases the protein and gene levels of ZO1 and Occludin in NPSLE model mouse (MRL/lpr mice) brain.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    K-7174 dihydrochloride is an orally active proteasome and GATA inhibitor. K-7174 dihydrochloride is a cell adhesion inhibitor. K-7174 dihydrochloride induces cell apoptosis. K-7174 dihydrochloride shows antitumor activities, it can be used for the research of cancer[1][2][3].

    体外研究
    (In Vitro)

    K-7174 dihydrochloride (10 μM; 1 h) inhibits the adhesion by VCAM-1 and its ligand[1].
    K-7174 dihydrochloride (1-30 μM; 1 h) dose-dependently suppresses the VCAM-1 expression with an IC50 value of 14 μM[1].
    K-7174 dihydrochloride (1-30 μM; 1 h) dose-dependently suppresses the induction of VCAM-1 mRNA by TNFα with an IC50 value of 9 μM[1].
    K-7174 dihydrochloride (10-20 μM; 24 h) dose-dependently rescues Epo production by Hep3B cells[2].
    K-7174 dihydrochloride (2.5-30 μM; 24 h) inhibits the binding activity of GATA[2].
    K-7174 dihydrochloride (0-25 μM; 72 h) inhibits MM cells growth and induces cell apoptosis[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    K-7174 dihydrochloride 相关抗体:

    Cell Viability Assay[3]

    Cell Line: KMS12-BM, U266, and RPMI8226 cell lines
    Concentration: 0-25 μM
    Incubation Time: 72 h
    Result: Inhibited MM cells growth.

    Apoptosis Analysis[3]

    Cell Line: KMS12-BM, U266, and RPMI8226 cell lines
    Concentration: 10 μM
    Incubation Time: 48 h
    Result: Significantly increased apoptosis of MM cells with the increasing percentage of annexin-V-positive cells.
    体内研究
    (In Vivo)

    K-7174 dihydrochloride (30 mg/kg; i.p. once daily for 9 days) reverses the decreasing of hemoglobin concentrations and reticulocyte counts by IL-1β or TNF-α[2].
    K-7174 dihydrochloride (75 mg/kg; i.p. once daily for 14 days) inhibits the tumor growth in vivo[3].
    K-7174 dihydrochloride (50 mg/kg; p.o. once daily for 14 days) inhibits the tumor growth in vivo and shows a better effect than intraperitoneal injection[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: ICR mice with IL-β or TNF-α injection[2]
    Dosage: 30 mg/kg
    Administration: Intraperitoneal injection; 30 mg/kg once daily for 9 days
    Result: Increased erythropoietin (Epo) production, reticulocyte counts, and hemoglobin (Hb) concentrations.
    Animal Model: NOD/SCID mice with murine xenograft[3]
    Dosage: 75 mg/kg
    Administration: Intraperitoneal injection; once daily for 14 days
    Result: Significantly decreased tumor volume, but showed a significant body weight reduction after 10 days.
    Animal Model: NOD/SCID mice with murine xenograft[3]
    Dosage: 50 mg/kg
    Administration: Oral gavage; once daily for 14 days
    Result: Showed an anti-myeloma activity. Porved oral administration is more effective than intraperitoneal injection.
    分子量

    641.67

    Formula

    C33H50Cl2N2O6
    CAS 号
    性状

    固体

    颜色

    White to yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    In Vitro: 

    H2O 中的溶解度 : 15 mg/mL (23.38 mM; 超声加热助溶)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.5584 mL 7.7922 mL 15.5843 mL
    5 mM 0.3117 mL 1.5584 mL 3.1169 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    In Vivo:

    以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： PBS

      Solubility: 10 mg/mL (15.58 mM); 澄清溶液; 超声助溶

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 98.19%

    COA (190 KB) HNMR (171 KB) LCMS (485 KB)

    产品使用指南 (1538 KB)
    参考文献

    K-7174 dihydrochloride 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.5584 mL 7.7922 mL 15.5843 mL 38.9608 mL
    5 mM 0.3117 mL 1.5584 mL 3.1169 mL 7.7922 mL
    10 mM 0.1558 mL 0.7792 mL 1.5584 mL 3.8961 mL
    15 mM 0.1039 mL 0.5195 mL 1.0390 mL 2.5974 mL
    20 mM 0.0779 mL 0.3896 mL 0.7792 mL 1.9480 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    K-7174191089-60-8K7174K 7174ProteasomeApoptosishomopiperazine derivativebortezomibcell adhesionapoptosisantitumorInhibitorinhibitorinhibit

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    目录号：
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