2. Anti-infection
  3. Bacterial Antibiotic
  4. Kanamycin sulfate

Kanamycin sulfate  (Synonyms: 硫酸卡那霉素; Kanamycin A sulfate)

目录号: HY-16566A 纯度: 99.96%
COA 产品使用指南

摩尔计算器

Kanamycin (Kanamycin A) sulfate 是一种口服有效的抗菌剂 (革兰氏阴性/阳性细菌)，可通过与 70 S 核糖体亚单位结合，抑制转位并导致编码错误。Kanamycin sulfate 对 M. tuberculosis (敏感或耐药) 以及 K. pneumonia 均具有较好的抑制活性，可用于肺结核和肺炎的研究。

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Kanamycin sulfate Chemical Structure

Kanamycin sulfate Chemical Structure

CAS No. : 25389-94-0

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥500
In-stock
200 mg ￥350
In-stock
1 g ￥450
In-stock
5 g ￥880
In-stock
10 g   询价  
50 g   询价  

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Customer Review

Other Forms of Kanamycin sulfate:

Kanamycin sulfate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia[1][2][3][4].

体外研究
(In Vitro)

Kanamycin sulfate (0.1-100 μg/mL; 2 weeks) exhibits good antibacterial activity (MIC=1-5 μg/mL) to various strains of mycobacteria in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kanamycin sulfate 相关抗体:

Cell Viability Assay[1]

Cell Line: mycobacteria H37Rv, H2, H37RvR-PAS, Ravenel, Kirchbergand and BCG.
Concentration: 0.1-100 μg/mL
Incubation Time: 2 weeks
Result: Showed good antibacterial activity to various strains of mycobacteria (H37Rv, H2, H37RvR-PAS, Ravenel, and BCG) with MICs were 1 μg/mL and 5 μg/mL for strain of Kirchbergand.
体内研究
(In Vivo)

Kanamycin sulfate (2, 4 mg/kg; s.c.; once daily, 6 times a week for 3 weeks) inhibits growth of bovine tubercle bacilli in lung and spleen of mice[1].
Kanamycin sulfate (1.25, 5 mg/kg; s.c.; single (at 3 h after infection)) inhibits the multiplication of K. pneumonia DT-S in lung, trachea, and blood of mice and in proportion to the dose administration, and also increases the survival rate of mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Inbred strain normal mice (14-16 g; bovine tubercle bacilli (Ravenel strain) infected model)[1].
Dosage: 2, 4 mg/kg
Administration: Subcutaneous injection; once daily, 6 times a week for 3 weeks.
Result: Exerted a marked effect to inhibit the multiplication of the tuberculosis in vivo, especially in the lung of mice.
Animal Model: Slc:ICR male mice (4-week-old; 18-24 g; K. pneumonia DT-S infection model (by the aerosol method))[2].
Dosage: 1.25, 5 mg/kg
Administration: Subcutaneous administration; single (at 3 h after infection).
Result: Suppressed the growth of K. pneumonia DT-S in lung, trachea, and blood in proportion to the dose administration.
Resulted in 90% survival at 6 days after infection (negative control group: all died within 4 days), and cleared the K. pneumonia DT-S from lung, trachea, and blood of mice within 48 h (when dosage at 5 mg/kg).
Clinical Trial
分子量

582.58

Formula

C18H38N4O15S
CAS 号
性状

固体

颜色

White to off-white

中文名称

硫酸卡那霉素；单硫酸卡那霉素；硫酸卡那辛
结构分类
初始来源

Streptomyces kanamyceticus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : ≥ 25 mg/mL (42.91 mM)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7165 mL 8.5825 mL 17.1650 mL
5 mM 0.3433 mL 1.7165 mL 3.4330 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 50 mg/mL (85.83 mM); 澄清溶液; 超声助溶

  • 方案 二

    请依序添加每种溶剂： Saline

    Solubility: 50 mg/mL (85.83 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.96%

COA (201 KB) HNMR (234 KB) RP-HPLC (244 KB) MS (69 KB)

产品使用指南 (1538 KB)
参考文献

Kanamycin sulfate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7165 mL 8.5825 mL 17.1650 mL 42.9126 mL
5 mM 0.3433 mL 1.7165 mL 3.4330 mL 8.5825 mL
10 mM 0.1717 mL 0.8583 mL 1.7165 mL 4.2913 mL
15 mM 0.1144 mL 0.5722 mL 1.1443 mL 2.8608 mL
20 mM 0.0858 mL 0.4291 mL 0.8583 mL 2.1456 mL
25 mM 0.0687 mL 0.3433 mL 0.6866 mL 1.7165 mL
30 mM 0.0572 mL 0.2861 mL 0.5722 mL 1.4304 mL
40 mM 0.0429 mL 0.2146 mL 0.4291 mL 1.0728 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

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