2. JAK/STAT Signaling Stem Cell/Wnt Anti-infection
  3. STAT Antibiotic Parasite
  4. Niclosamide monohydrate

Niclosamide monohydrate  (Synonyms: 氯硝柳胺一水合物; BAY2353 monohydrate)

目录号: HY-B0497B
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摩尔计算器

Niclosamide (BAY2353) monohydrate 是一种具有口服活性的用于寄生虫感染研究的抗蠕虫化合物。Niclosamide monohydrate 是 STAT3 抑制剂，在 HeLa 细胞中的 IC50 为 0.25 μM。Niclosamide monohydrate 具有抗癌的生物活性，并能抑制 Vero E6 细胞的 DNA 复制。

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Niclosamide monohydrate Chemical Structure

Niclosamide monohydrate Chemical Structure

CAS No. : 73360-56-2

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Niclosamide monohydrate 的其他形式现货产品:

Other Forms of Niclosamide monohydrate:

Niclosamide monohydrate 相关抗体

Top Publications Citing Use of Products

    Niclosamide monohydrate purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC; 0-8 μM; 24, 48, 72 h) significantly inhibits the metabolic viability of AN3CA, Hec1B, and Ishikawa cells both in a dose-dependent and a time-dependent manner, with the half maximal inhibitory concentration of < 1 μM at 72 h.

    Niclosamide monohydrate purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC; 5 μM; 24 h) significantly reduces cyclin D1 and vimentin protein expression in human endometrial cancer cells.

    Niclosamide monohydrate purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC; 1 μM) reduces number of cells that invaded across the trans-well chamber in Hec1B and Ishikawa endometrial cancer cell lines, suggesting NIC-mediated inhibition of invasive property of endometrial cancer cells.

    Niclosamide monohydrate purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 May.

    Niclosamide (NIC) significantly suppresses the colony formation ability, and reduces the numbers, as well as diameters, of colonies formed in AN3CA, Hec1B, and Ishikawa cells.

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research[1]. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[2][3][5].

    IC50 & Target[1]

    STAT3

    0.25 μM (IC50, in HeLa cells)

    体外研究
    (In Vitro)

    Niclosamide monohydrate (0.6 nM-46 µM) treatment inhibits adrenocortical carcinoma cellular proliferation in BD140A, SW-13, and NCI-H295R cells[3].
    Niclosamide monohydrate (0.05-5 μM, 24 h) treatment inhibits STAT3-mediated luciferase reporter activity in HeLa cells [4].
    Niclosamide monohydrate (10 μM) treatment inhibits virus replication in Vero E6 cells[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Niclosamide monohydrate 相关抗体:

    Cell Viability Assay[3]

    Cell Line: BD140A, SW-13 and NCI-H295R cells
    Concentration: 0.6 nM-46 µM
    Incubation Time:
    Result: Inhibited cellular proliferation in adrenocortical carcinoma cell lines with the IC50 of 0.12 µM, 0.15 µM, and 0.53 µM in BD140A, SW-13, and NCI-H295R, respectively.

    Cell Viability Assay[4]

    Cell Line: Hela cells
    Concentration: 0.05-5 μM
    Incubation Time: 24 hours
    Result: Inhibited STAT3-mediated luciferase reporter activity with an IC50 of 0.25 μM.

    Cell Viability Assay[5]

    Cell Line: Vero E6 cells
    Concentration: 10 μM
    Incubation Time: 2 days
    Result: Inhibited the synthesis of viral antigens of SARS-CoV in Vero E6 cells.
    体内研究
    (In Vivo)

    Niclosamide monohydrate (oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks) treatment inhibits adrenocortical carcinoma tumor growth in vivo[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Nu+/Nu+ mice injected with NCI-H295R cells[3]
    Dosage: 100 mg/kg, 200 mg/kg
    Administration: Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks
    Result: Showed a 60%-80% inhibition in tumor growth, as compared to the control group.
    Clinical Trial
    分子量

    345.13

    Formula

    C13H10Cl2N2O5
    CAS 号
    中文名称

    氯硝柳胺一水合物
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Niclosamide monohydrate 相关分类

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    • Do most proteins show cross-species activity?

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    Keywords:

    Niclosamide73360-56-2BAY2353氯硝柳胺一水合物BAY 2353BAY-2353STATAntibioticParasiteBD140ASW-13NCI-H295RHelaVero E6antihelminthicbayluscideInhibitorinhibitorinhibit

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