1. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  2. Glucocorticoid Receptor
  3. ORIC-101

ORIC-101 是一种有效、选择性的糖皮质激素受体 (glucocorticoid receptor) 拮抗剂,EC50 值为 5.6 nM。抗癌作用。

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ORIC-101 Chemical Structure

ORIC-101 Chemical Structure

CAS No. : 2222344-98-9

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1 mg ¥6200
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC50 of 5.6 nM. Anti-cancer activity. ORIC-101 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

EC50: 5.6 nM (Glucocorticoid receptor)[1]

体外研究
(In Vitro)

ORIC-101 shows markedly reduced androgen receptor agonism (EC50, 2500 nM) and CYP2C8 and CYP2C9 inhibition profiles (IC50, >10 μM)[1].
ORIC-101 (1-1000 nM) dose-dependently reduces the expression of n GR-mediated target gene (FKBP5 and GILZ), with IC50s of 17.2 and 21.2 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

ORIC-101 (75 mg/kg, P.O. twice a day for 16-22 days) enhances the anti-tumor activity in combination with gemcitabine and carboplatin in OVCAR5 xenograft tumor in cortisol-treated mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: OVCAR5 xenograft tumor in cortisol-treated mice[1]
Dosage: 75 mg/kg with 100 mg/kg gemcitabine and 60 mg/kg carboplatin
Administration: P.O. twice a day for 16-22 days
Result: Significantly reduced tumor volume in combination with chemotherapeutic agents.
Clinical Trial
分子量

501.74

Formula

C34H47NO2

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 100 mg/mL (199.31 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9931 mL 9.9653 mL 19.9306 mL
5 mM 0.3986 mL 1.9931 mL 3.9861 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.30%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9931 mL 9.9653 mL 19.9306 mL 49.8266 mL
5 mM 0.3986 mL 1.9931 mL 3.9861 mL 9.9653 mL
10 mM 0.1993 mL 0.9965 mL 1.9931 mL 4.9827 mL
15 mM 0.1329 mL 0.6644 mL 1.3287 mL 3.3218 mL
20 mM 0.0997 mL 0.4983 mL 0.9965 mL 2.4913 mL
25 mM 0.0797 mL 0.3986 mL 0.7972 mL 1.9931 mL
30 mM 0.0664 mL 0.3322 mL 0.6644 mL 1.6609 mL
40 mM 0.0498 mL 0.2491 mL 0.4983 mL 1.2457 mL
50 mM 0.0399 mL 0.1993 mL 0.3986 mL 0.9965 mL
60 mM 0.0332 mL 0.1661 mL 0.3322 mL 0.8304 mL
80 mM 0.0249 mL 0.1246 mL 0.2491 mL 0.6228 mL
100 mM 0.0199 mL 0.0997 mL 0.1993 mL 0.4983 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

产品名称:
ORIC-101
目录号:
HY-112710
需求量: