1. Anti-infection
  2. Beta-lactamase Bacterial Antibiotic
  3. Penicillin G sodium salt

Penicillin G sodium salt  (Synonyms: 青霉素钠; Benzylpenicillin sodium salt)

目录号: HY-B1463 纯度: 98.06%
COA 产品使用指南

Penicillin G sodium salt 是一种典型的 β-内酰胺类抗生素。

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Penicillin G sodium salt Chemical Structure

Penicillin G sodium salt Chemical Structure

CAS No. : 69-57-8

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100 mg ¥390
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500 mg   询价  

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Other Forms of Penicillin G sodium salt:

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Top Publications Citing Use of Products
  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Penicillin G sodium salt is a typical β-lactam antibiotic.

IC50 & Target

β-lactam

 

体外研究
(In Vitro)

The Ultraviolet-visible (UV-Vis) absorption spectrum of the Penicillin G sodium salt-TEM-1 system is markedly different to that of Penicillin G sodium salt and TEM-1 β-lactamase, indicating the formation of new complexes between Penicillin G sodium salt and TEM-1 β-lactamase. The UV-Vis absorption of TEM-1 β-lactamase increases and a slight red-shift occurs as the concentration of Penicillin G sodium salt increasing, indicating that the interaction between Penicillin G sodium salt and TEM-1 β-lactamase results in subtle conformational changes of TEM-1 β-lactamase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

In the logistic regression model, the probability of a positive swab in the control group is 1.6 times higher than that in the pigs treated with Penicillin G sodium salt (P<0.05). In the control group, the risk of a swab having 10 to 99 colonies per plate, compare to having zero per plate, is 2.3 times greater than that in the pigs treated with Penicillin G sodium salt (P=0.022)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

356.37

Formula

C16H17N2NaO4S

CAS 号
性状

固体

颜色

White to off-white

中文名称

青霉素钠

结构分类
初始来源

Penicillium

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

溶解性数据
In Vitro: 

H2O 中的溶解度 : 125 mg/mL (350.76 mM; 超声助溶)

DMSO 中的溶解度 : 100 mg/mL (280.61 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8061 mL 14.0304 mL 28.0607 mL
5 mM 0.5612 mL 2.8061 mL 5.6121 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.02 mM); 澄清溶液

    此方案可获得 ≥ 2.5 mg/mL(饱和度未知)的澄清溶液。

    1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;再向上述体系中加入 50 μL Tween-80,混合均匀;然后再继续加入 450 μL 生理盐水 定容至 1 mL

    生理盐水的配制:将 0.9 g 氯化钠,溶解于 ddH₂O 并定容至 100 mL,可以得到澄清透明的生理盐水溶液。
  • 方案 二

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.02 mM); 澄清溶液

    此方案可获得 ≥ 2.5 mg/mL(饱和度未知)的澄清溶液。

    1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中,混合均匀。

    20% SBE-β-CD in Saline 的配制(4°C,储存一周):2 g SBE-β-CD(磺丁基醚 β-环糊精)粉末定容于 10 mL 的生理盐水中,完全溶解至澄清透明。

以下溶解方案,请直接配置工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂: PBS

    Solubility: 100 mg/mL (280.61 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献
Kinase Assay
[1]

At 278 K, various concentrations of Penicillin G sodium salt, cefalexin and cefoxitin solutions are added to TEM-1β-lactamase solution (5×10-6 M). The concentrations of the three antibiotics are gradually increased from 0 to 25×10-6 M. Following mixing and interaction for 2 min, the Ultraviolet-visible (UV-Vis) absorption spectra are recorded on a spectrophotometer with a slit of 2 nm and scanning speed of 400 nm/min using 0.02 M phosphate buffer (pH 7.0) as a reference[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[2]

A randomized complete block design with 2 replicates is used for this study. Each replicate includes 448 pigs, with 16 pens and 28 pigs per pen. Pigs are also sorted by weight; such that animals of similar weight based on visual observation are grouped together within blocks. Two treatments are randomly assigned within each block of 2 contiguous pens using a formal randomization process. The treatment groups are Control (no treatment given) and Treated (Penicillin G sodium salt). Penicillin G sodium salt is administered via the drinking water for 5 d over 2 periods of treatment. The first treatment period commences on the day of weaning, when the pigs are moved into the nursery barns (Day 1) and ends on Day 5. The second treatment period begins on Day 21 and ends on Day 25. The Control group does not receive treatment[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

Penicillin G sodium salt 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.8061 mL 14.0304 mL 28.0607 mL 70.1518 mL
5 mM 0.5612 mL 2.8061 mL 5.6121 mL 14.0304 mL
10 mM 0.2806 mL 1.4030 mL 2.8061 mL 7.0152 mL
15 mM 0.1871 mL 0.9354 mL 1.8707 mL 4.6768 mL
20 mM 0.1403 mL 0.7015 mL 1.4030 mL 3.5076 mL
25 mM 0.1122 mL 0.5612 mL 1.1224 mL 2.8061 mL
30 mM 0.0935 mL 0.4677 mL 0.9354 mL 2.3384 mL
40 mM 0.0702 mL 0.3508 mL 0.7015 mL 1.7538 mL
50 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.4030 mL
60 mM 0.0468 mL 0.2338 mL 0.4677 mL 1.1692 mL
80 mM 0.0351 mL 0.1754 mL 0.3508 mL 0.8769 mL
100 mM 0.0281 mL 0.1403 mL 0.2806 mL 0.7015 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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