2. Metabolic Enzyme/Protease Anti-infection
  3. Elastase SARS-CoV
  4. Sivelestat sodium

Sivelestat sodium  (Synonyms: 西维来司钠; ONO5046-Na; Sodium sivelestat; EI546 sodium; LY544349 sodium)

目录号: HY-17443A 纯度: 99.77%
COA 产品使用指南 技术支持

Sivelestat (EI546) sodium 是竞争性的人类中性粒细胞弹性蛋白酶的抑制剂，其IC50 值为 44 nM， Ki 值为 200 nM。Sivelestat (EI546) sodium 有潜力用于COVID-19 的急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的研究。

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Sivelestat sodium

Sivelestat sodium Chemical Structure

CAS No. : 150374-95-1

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥770
In-stock
5 mg ￥437
In-stock
10 mg ￥700
In-stock
25 mg ￥1500
In-stock
50 mg ￥2400
In-stock
100 mg ￥3850
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Other Forms of Sivelestat sodium:

Sivelestat sodium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sivelestat (EI546) sodium is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4].

体外研究
(In Vitro)

Sivelestat (ONO-5046) does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM[1].
Sivelestat (ONO-5046) exhibits IC50 values of 44 nM, 36 nM, 19 nM, 37 nM and 49 nM for human, rabbit, rat, hamster and mouse neutrophil elastase, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sivelestat sodium 相关抗体:
体内研究
(In Vivo)

Sivelestat (ONO-5046, 0.021-2.1 mg/kg, intratracheally) suppresses lung hemorrhage in hamster (ID50 = 82 pg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which are induced by human neutrophil elastase[1].
Sivelestat (10 mg/kg, infusion via the tail vein) ameliorates lung injury after hemorrhagic shock in rats[2].
Sivelestat (15, 60 mg/kg, ip) prevents ischemia–reperfusion injury in the rat bladder[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Golden hamsters, weighing 90 to 110 g[1].
Dosage: 0.021-2.1 mg/kg.
Administration: Intratracheally five min before HNE injection.
Result: Significantly and dosedependently suppressed the lung hemorrhage.
Animal Model: Male Sprague-Dawley rats weighing 350-400 g[2].
Dosage: 10 mg/kg.
Administration: Continuous infusion via the tail vein at 10 mg/kg/h for 60 min during the resuscitation phase.
Result: Greatly suppressed lung injury, as revealed by the reduced histological damage.
Significantly ameliorated HSR-induced lung injury.
Markedly decreased the levels of TNF-α and iNOS gene.
Animal Model: Male Sprague Dawley rats, 8 weeks old and weighing 250-320 g[3].
Dosage: 15 mg/kg or 60 mg/kg.
Administration: IP.
Result: Decreased the blood flow in the bladder during reperfusion phase compared to the IR group.
Clinical Trial
分子量

456.44

Formula

C20H21N2NaO7S
CAS 号
性状

固体

颜色

White to off-white

中文名称

西维来司钠
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (219.09 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1909 mL 10.9543 mL 21.9087 mL
5 mM 0.4382 mL 2.1909 mL 4.3817 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.77%

COA (286 KB) LCMS (106 KB)

产品使用指南 (1538 KB)
参考文献

Sivelestat sodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1909 mL 10.9543 mL 21.9087 mL 54.7717 mL
5 mM 0.4382 mL 2.1909 mL 4.3817 mL 10.9543 mL
10 mM 0.2191 mL 1.0954 mL 2.1909 mL 5.4772 mL
15 mM 0.1461 mL 0.7303 mL 1.4606 mL 3.6514 mL
20 mM 0.1095 mL 0.5477 mL 1.0954 mL 2.7386 mL
25 mM 0.0876 mL 0.4382 mL 0.8763 mL 2.1909 mL
30 mM 0.0730 mL 0.3651 mL 0.7303 mL 1.8257 mL
40 mM 0.0548 mL 0.2739 mL 0.5477 mL 1.3693 mL
50 mM 0.0438 mL 0.2191 mL 0.4382 mL 1.0954 mL
60 mM 0.0365 mL 0.1826 mL 0.3651 mL 0.9129 mL
80 mM 0.0274 mL 0.1369 mL 0.2739 mL 0.6846 mL
100 mM 0.0219 mL 0.1095 mL 0.2191 mL 0.5477 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sivelestat150374-95-1ONO5046-Na Sodium sivelestatEI546LY544349西维来司钠EI 546EI-546LY 544349LY-544349ElastaseSARS-CoVSARS coronavirusAcutelunginjuryischemiareperfusionInhibitorinhibitorinhibit

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