1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Aldose Reductase

Aldose Reductase

Aldose reductase is an NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the reduction of glucose to sorbitol, the first step in polyol pathway of glucose metabolism. The aldose reductase reaction, in particular the sorbitol produced, is important for the function of various organs in the body. Aldose reductase inhibitors are a class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes.

Aldose Reductase 相关产品 (12):

Cat. No. Product Name Effect Purity
  • HY-N0102
    Isoliquiritigenin Inhibitor 98.24%
    Isoliquiritigenin 是从光果甘草根中分到的黄酮类化合物,具有抗肿瘤的活性,能够抑制 aldose reductase 的活性,IC50 值为 320 nM。
  • HY-66009
    Epalrestat Inhibitor >98.0%
    Epalrestat是醛糖还原酶抑制剂,可作用于糖尿病神经病变。
  • HY-16500
    Tolrestat Inhibitor 98.85%
    Tolrestat 是一种有效的,可口服的 aldose reductase 抑制剂,IC50 值为 35 nM。
  • HY-15314
    Ranirestat Inhibitor 99.14%
    Ranirestat (AS-3201)是醛糖还原酶抑制剂,糖尿病性神经病变临床3期。
  • HY-B1202
    Alrestatin Inhibitor 99.14%
    Alrestatin是醛糖还原酶抑制剂, 醛糖还原酶是涉及糖尿病并发症发病机制的一种酶, 包括糖尿病性神经病。
  • HY-N6883
    6-Methoxytricin Inhibitor
    6-Methoxytricin (Compound 6) 6-甲氧基哌啶是从艾蒿 Artemisia iwayomogi 分离的类黄酮。6-Methoxytricin (Compound 6) 是醛糖还原酶 (AR) 和晚期糖基化终产物 (AGE) 的抑制剂,IC50 值分别为 30.29 μM 和 134.88 μM。6-Methoxytricin (Compound 6) 具有抗糖尿病并发症的潜力。
  • HY-N4089
    Quercetin 3-gentiobioside Inhibitor
    Quercetin 3-gentiobioside 槲皮素 3-龙胆二糖从 A. iwayomogi 中分离出来,ARAGE 形成的抑制剂,显示出抗醛糖还原酶 (AR) 的生物活性和晚期糖基化终产物 (AGEs) 的形成。
  • HY-18967
    Aldose reductase-IN-1 Inhibitor 99.86%
    Aldose reductase-IN-1是一种醛糖还原酶抑制剂, IC50值为28.9 pM。
  • HY-16255
    Imirestat Inhibitor 99.52%
    Imirestat (AL 1576) 是一种 aldose reductase 抑制剂,可用于治疗糖尿病。
  • HY-105185
    Fidarestat Inhibitor
    Fidarestat (SNK 860) 是一种醛糖还原酶 (aldose reductase) 抑制剂,对 aldose reductase,AKR1B10 和 V301L AKR1B10 的 IC50 值分别为 26 nM,33 μM 和 1.8 μM;Fidarestat (SNK 860) 具有治疗糖尿病的潜力。
  • HY-16433
    Risarestat Inhibitor
    Risarestat (CT-112)是一种醛糖还原酶抑制剂,开发用于治疗糖尿病并发症。
  • HY-B1202A
    Alrestatin sodium Inhibitor
    Alrestatin钠是醛糖还原酶抑制剂, 醛糖还原酶是涉及糖尿病并发症发病机制的一种酶, 包括糖尿病性神经病。
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