1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Stearoyl-CoA Desaturase (SCD)

Stearoyl-CoA Desaturase (SCD) (硬脂酰辅酶A去饱和酶)

Stearoyl-CoA desaturase (SCD) is a key regulator of membrane fluidity, turns over rapidly, and represents a model for selective degradation of short-lived proteins of the endoplasmic reticulum (ER). SCD is a rate-limiting lipogenic enzyme that plays an integral role in catalyzing the synthesis of monounsaturated fatty acids, chiefly oleate and palmitoleate. Both contribute a major part of the biological membrane. Numerous SCD isoforms exist in mouse and humans, i.e., SCD-1 to SCD-4 and SCD-1 and SCD-5, respectively.

Overexpression of SCD is evident and implicated in metabolic diseases such as diabetes and non-alcoholic fatty liver disease. SCD also stimulates canonical Wnt pathway and YAP activation in support of stemness and tumorigenesis. SCD facilitates metabolic reprogramming in cancer which is mediated, at least in part, by regulation of AKT, AMPK, and NF-kB via MUFAs. From the biological viewpoint, hyperexpression of SCD1 causes many metabolic disorders including obesity, insulin resistance, hypertension, and hypertriglyceridemia, etc. SCD1 is a pharmacological target in the treatment of obesity, diabetes and other metabolic diseases.

Stearoyl-CoA Desaturase (SCD) 相关产品 (8):

目录号 产品名 作用方式 纯度
  • HY-15700
    PluriSIn 1 Inhibitor 99.64%
    PluriSIn 1 (NSC 14613) 是一种酰基-辅酶A去饱和酶 (SCD) 抑制剂,是一种多能细胞特异性的抑制剂。
  • HY-15822
    MF-438 Inhibitor 99.92%
    MF-438 是一种有效且口服生物可利用的 stearoyl-CoA desaturase 1 (SCD1) 的抑制剂,对 rSCD1 的 EC50 值为 2.3 nM。
  • HY-N6807
    Elemicin Inhibitor 98.39%
    Elemicin 是一种烯基苯,广泛分布于许多草药和香料中。Elemicin 通过代谢激活抑制硬脂酰辅酶 A 去饱和酶 1 (SCD1)。Elemicin 是芳香族食品中的主要成分之一,具有抗微生物,抗氧化剂和抗病毒活性。Elemicin 具有遗传毒性和致癌性。
  • HY-11034
    CVT-12012 Inhibitor 98.97%
    CVT-12012 是一种有效的、具有口服活性的硬脂酰-CoA 去饱和酶 (SCD) 的抑制剂,其对大鼠微粒体和人 HEPG2 的 IC50 值分别为 38 nM,6.1 nM。
  • HY-112812
    SCD1 inhibitor-1 Inhibitor 99.45%
    SCD1 inhibitor-1 是有效、肝靶向的硬脂酰 -CoA 去饱和酶 (SCD1) 抑制剂。
  • HY-139077
    SCD1 inhibitor-3 Inhibitor
    SCD1 inhibitor-3 是一种安全、有效的具有口服活性的 SCD1 抑制剂。SCD1 inhibitor-3 可用于肥胖症、二型糖尿病、血脂异常等代谢性疾病,以及皮肤病、痤疮、癌症等的研究。
  • HY-141525
    SCD1 inhibitor-4 Inhibitor
    SCD1 inhibitor-4 是一种有效的、口服活性 stearoylCoA desaturase-1 (SCD1) 抑制剂。SCD1 inhibitor-4 可用于糖尿病的研究。
  • HY-13077
    MK-8245 Trifluoroacetate Inhibitor 98.09%
    MK-8245三氟醋酸盐是肝靶向的硬脂酰-CoA去饱和酶(SCD)抑制剂,对人SCD1和鼠SCD1的IC50分别为1 nM和3 nM。
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