1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. FBPase

FBPase (果糖-1,6-双磷酸酯酶)


FBPase, which catalyses the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate, is a rate-limiting enzyme responsible for gluconeogenesis and glyconeogenesis and, more generally, for the control of energy metabolism and glucose homeostasis. In mammals, two separate genes, FBP1 and FBP2, encode the liver and muscle isoforms of FBPase, respectively.

Lower FBPase expression frequently correlated significantly with an advanced tumour stage, a highly malignant phenotype, and worse prognoses in cancer patients. All these data implied that FBPase might be a novel biomarker and potential target for the treatment of cancer.

FBPase 相关产品 (5):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16307
    MB05032 Inhibitor 99.66%
    MB05032 是一种糖异生抑制剂,能靶向果糖-1,6-双磷酸酯酶的 AMP 结合位点,IC50为 16 nM。
  • HY-136717
    FBPase-1 inhibitor-1 Inhibitor 99.10%
    FBPase-1 inhibitor-1 (compound 1) 是 fructose-1,6-bisphosphatase (FBPase-1) 变构抑制剂。
    FBPase-1 inhibitor-1
  • HY-14955
    Managlinat dialanetil


    Inhibitor 98.13%
    Managlinat dialanetil (MB06322) 是一种可口服利用的 fructose 1,6-bisphosphatase (FBPase) 抑制剂,作用于 2 型糖尿病。
    Managlinat dialanetil
  • HY-146725
    FBPase-IN-1 Inhibitor 98.30%
    FBPase-IN-1 是一种有效的 FBPase (Fructose-1,6-bisphosphatase) 抑制剂,IC50 为 0.22 μM,可用于二型糖尿病研究。FBPase-IN-1 可降低血糖水平,改善糖耐量。FBPase-IN-1 修饰 C128 位点,调控 FBPase 的 N125-S124-S123 变构通路,影响 FBPase 的催化活性。
  • HY-147645
    FBPase-IN-2 Inhibitor
    FBPase-IN-2 (HS36) 是一种有效的果糖-1,6-二磷酸酶 (FBPase) 共价抑制剂,IC50 值为 0.15 μM。FBPase-IN-2 降低肝细胞内葡萄糖的生成。FBPase-IN-2 可用于二型糖尿病的研究。