Pirmenol  (Synonyms: (±)-Pirmenol; CI-845 free base)

Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits I_K.ACh (IC₅₀: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation^[1][2][4].

IC50: 0.1 μM (I_K.ACh)^[1]

Pirmenol (1 μM) inhibits the I_K.ACh induced by carbachol or intracellular loading of GTPg S in in atrial cells^[1].
Pirmenol (5 μM) depresses the early part of the plateau and lengthened the final repolarization of the action potentials in ventricular myocytes^[3].
Pirmenol (1 μM) prolongs the action potential duration at 90% repolarization in atrial muscles and Purkinje fibers^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pirmenol (2.5 and 5 mg/kg, p.o.) is effective against the arrhythmias in conscious, coronary artery ligated dogs^[4].
Pirmenol (rats) shows LD₅₀s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.)^[2].
Pirmenol (mice) shows LD₅₀s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.)^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

338.49

C₂₂H₃₀N₂O

68252-19-7

吡美诺；吡哌醇

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Watanabe Y, et al. Pirmenol inhibits muscarinic acetylcholine receptor-operated K+ current in the guinea pig heart. Eur J Pharmacol. 1997 Oct 29;338(1):71-4.  [Content Brief]

  [2]. Schardein JL, et al. Preclinical toxicology studies with a new antiarrhythmic agent: Pirmenol hydrochloride (CI-845). Toxicol Appl Pharmacol. 1980 Nov;56(2):294-301.  [Content Brief]

  [3]. T Sawanobori, et al. Electrophysiologic and antiarrhythmic actions of pirmenol on rabbit and guinea pig cardiac preparations. J Cardiovasc Pharmacol. 1990 Dec;16(6):975-83.  [Content Brief]

  [4]. T E Mertz, et al. Pirmenol hydrochloride (CI-845): antiarrhythmic profile in coronary artery ligated conscious dogs. J Cardiovasc Pharmacol. 1980 Sep-Oct;2(5):527-41.  [Content Brief]