2. Neuronal Signaling
  3. Amyloid-β Cholinesterase (ChE) Monoamine Oxidase
  4. AChE-IN-12

AChE-IN-12 是一种有效的、具有血脑屏障 (BBB) 渗透性的乙酰胆碱酯酶 (AChE) 抑制剂，对大鼠 AChE 和电鳗 AChE 的 IC50 分别为 0.41 μM 和 1.88 μM。AChE-IN-12 还是一种良好的抗氧化剂 (ORAC = 3.3 eq)、选择性金属螯合剂和 huMAO-B 抑制剂 (IC50 = 8.8 µM)。AChE-IN-12 对 Cu2+ 诱导的 Aβ1-42 聚集有显著抑制作用，并具有出良好的神经保护作用。可用于研究阿尔兹海默症。

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AChE-IN-12 Chemical Structure

AChE-IN-12 Chemical Structure

CAS No. : 2764664-52-8

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AChE-IN-12 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC50s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC50 = 8.8 µM). AChE-IN-12 has remarkable inhibition of self- and Cu2+-induced Aβ1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease[1].

IC50 & Target

IC50: 0.41 μM (rat AChE), 1.88 μM (electric eel AChE), 8.8 µM (huMAO-B)[1]
体外研究
(In Vitro)

AChE-IN-12 (compound 17f）(10-100 μM) exhibits no obvious cytotoxicity until the concentration increased up to 50 µM[1].
AChE-IN-12 (10 and 50 μM) adds up the cell viability of H2O2-induced PC12 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-12 相关抗体:

Cell Cytotoxicity Assay

Cell Line: PC12 cells[1]
Concentration: 10, 50 and 100 μM
Incubation Time:
Result: Did not show obvious cytotoxicity until the concentration increased up to 50 µM.

Cell Viability Assay

Cell Line: PC12 cells (exposed to 100 µM H2O2 for 1 hour to establish the oxidative damage model)[1]
Concentration: 10 and 50 μM
Incubation Time:
Result: Added up the cell viability to 65.7% (p < 0.05) and 73.4% (p < 0.05) at 10 and 50 μM, respectively.
分子量

563.68

Formula

C33H41NO7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE-IN-12 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-122764664-52-8Amyloid-βCholinesterase (ChE)Monoamine Oxidaseβ-amyloid peptideAβAbetaMAOChalcone-Vitamin E-donepezil hybridsAlzheimer’s diseaseBlood-brain barrierNeuroprotectiveAntioxidantPC12 cellsInhibitorinhibitorinhibit

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