2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Acotiamide

Acotiamide  (Synonyms: Z-338 free base; YM443 free base)

目录号: HY-121467 纯度: 99.92%
COA 产品使用指南 技术支持

Acotiamide 是一种口服有效的、具有选择性和可逆性的乙酰胆酶碱酯酶 (AChE) 抑制剂,其 IC50 值为 1.79 μM。Acotiamide 可增强胃收缩性并加速胃排空延迟。Acotiamide 可用于胃动力障碍的功能性消化不良及肠道炎症的研究。

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Acotiamide Chemical Structure

Acotiamide Chemical Structure

CAS No. : 185106-16-5

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规格 价格 是否有货 数量
5 mg ￥160
In-stock
10 mg ￥270
In-stock
25 mg ￥540
In-stock
50 mg ￥870
In-stock
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200 mg   询价  

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Customer Review

Other Forms of Acotiamide:

Acotiamide 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory[1][2][3].

IC50 & Target

IC50: 1.79 μM (AChE)[3].
体外研究
(In Vitro)

Acotiamide (10, 30, 100 μM; 1 hour) reduces expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Acotiamide 相关抗体:

Cell Viability Assay[1]

Cell Line: NR8383, macrophage
Concentration: 10, 30, 100 μM
Incubation Time: 1 hour
Result: Significantly reduced both TNF-α and IL-6 productions in LPS/MCP-1-stimulated NR8383 cells.
体内研究
(In Vivo)

Acotiamide (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner[2].
Acotiamide (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with an IC50 value of 1.79 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg)[2]
Dosage: 0.3, 1, 3, 10, 30 mg/kg
Administration: Intravenous injection; once
Result: Increased the postprandial gastric motility.
Animal Model: Male Sprague-Dawley rats (aged 6-7 weeks)[3]
Dosage: 0.83 mg/kg
Administration: Intravenous injection; once.
Result: Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.
Clinical Trial
分子量

450.55

Formula

C21H30N4O5S
CAS 号
性状

固体

颜色

White to off-white

中文名称

阿考替胺杂质27
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 250 mg/mL (554.88 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2195 mL 11.0975 mL 22.1951 mL
5 mM 0.4439 mL 2.2195 mL 4.4390 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Acotiamide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2195 mL 11.0975 mL 22.1951 mL 55.4877 mL
5 mM 0.4439 mL 2.2195 mL 4.4390 mL 11.0975 mL
10 mM 0.2220 mL 1.1098 mL 2.2195 mL 5.5488 mL
15 mM 0.1480 mL 0.7398 mL 1.4797 mL 3.6992 mL
20 mM 0.1110 mL 0.5549 mL 1.1098 mL 2.7744 mL
25 mM 0.0888 mL 0.4439 mL 0.8878 mL 2.2195 mL
30 mM 0.0740 mL 0.3699 mL 0.7398 mL 1.8496 mL
40 mM 0.0555 mL 0.2774 mL 0.5549 mL 1.3872 mL
50 mM 0.0444 mL 0.2220 mL 0.4439 mL 1.1098 mL
60 mM 0.0370 mL 0.1850 mL 0.3699 mL 0.9248 mL
80 mM 0.0277 mL 0.1387 mL 0.2774 mL 0.6936 mL
100 mM 0.0222 mL 0.1110 mL 0.2220 mL 0.5549 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acotiamide185106-16-5Z-338YM443阿考替胺杂质27Z338Z 338YM 443YM-443Cholinesterase (ChE)gastric motilityfunctional dyspepsiaNR8383macrophageintestinal inflammatorygastric emptyingInhibitorinhibitorinhibit

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