2. Apoptosis
  3. TNF Receptor
  4. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) 

目录号: HY-P990809
技术支持

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) 是一种激动型大鼠源性 IgG1 κ 型抗体，靶向小鼠 4-1BB/CD137。Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) 可刺激 4-1BB 信号传导并诱导 T 细胞介导的抗肿瘤免疫。Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) 可用于癌症、感染、免疫学和神经疾病的研究，如胶质母细胞瘤和逆转录病毒感染。

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Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) Chemical Structure

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Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) is an agonistic rat-derived IgG1 κ type antibody, targeting to mouse 4-1BB/CD137. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can stimulate 4-1BB signaling and induce T cell mediated antitumor immunity. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease, such as glioblastoma and retrovirus infection[1][2].

同型

Rat IgG1 kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

4-1BB/CD137
体内研究
(In Vivo)

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) (200 μg，腹腔注射，从第 9 天起每 3 天一次) 与 anti-PD-1 (HY-P99144) 联合使用，可改善胶质母细胞瘤肿瘤浸润淋巴细胞的功能，并延长 CT2A 肿瘤小鼠的生存期[1]。
Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) (100 μg，腹腔注射，感染后第 4 天起每隔一天一次) 可略微增加 Friend 逆转录病毒感染小鼠中病毒特异性 CD4+ T 细胞的数量，并显著增强颗粒酶 B (GzmB) 的表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT2A tumor mice models[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, every 3 days from day 9
Result: Decreased co-expression of the immune checkpoints TIM-3 and LAG-3.
Decreased CD8+ tumor infiltrating lymphocytes co-expressing PD-1, TIM-3, and LAG-3.
Prolonged survival of mice.
基因 ID

21942  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)TNF ReceptorTumor Necrosis Factor ReceptorTNFR4-1BBCD137T cellGlioblastomaRetrovirusCT2AInhibitorinhibitorinhibit

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