2. Immunology/Inflammation
  3. CD22
  4. Anti-Mouse CD22 Antibody (Cy34.1)

Anti-Mouse CD22 Antibody (Cy34.1) 

目录号: HY-P990283
技术支持

Anti-Mouse CD22 Antibody (Cy34.1) 是一种小鼠源性 IgG1 κ 型抗体抑制剂，靶向小鼠 CD22。Anti-Mouse CD22 Antibody (Cy34.1) 可耗竭 CD22 细胞和 B 细胞。Anti-Mouse CD22 Antibody (Cy34.1) 可促进小胶质细胞吞噬作用。Anti-Mouse CD22 Antibody (Cy34.1) 可用于炎症和神经系统疾病的研究，如阿尔茨海默病 (AD) 和视神经脊髓炎。

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Anti-Mouse CD22 Antibody (Cy34.1)

Anti-Mouse CD22 Antibody (Cy34.1) Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Anti-Mouse CD22 Antibody (Cy34.1) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD22 Antibody (Cy34.1) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse CD22. Anti-Mouse CD22 Antibody (Cy34.1) can deplete CD22 cells and B cells. Anti-Mouse CD22 Antibody (Cy34.1) can promote microglial phagocytosis. Anti-Mouse CD22 Antibody (Cy34.1) can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease (AD) and neuromyelitis[1][2][3].

同型

Mouse IgG1 kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CD22
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD22 Antibody (Cy34.1) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CD22 Antibody (Cy34.1) (150 μg，腹腔注射，单剂量) 与抗 CD19 (HY-P99976) 和抗大鼠 κ 轻链 (HY-P990120) 联合使用可耗竭小鼠体内的 B 细胞[1]。
Anti-Mouse CD22 Antibody (Cy34.1) (1 mg/mL，脑内注射，单剂量) 可促进老年小鼠髓鞘碎片的清除[2]。
Anti-Mouse CD22 Antibody (Cy34.1) (1 mg/mL，脑内注射，单剂量) 可清除注射 Aβ 的老年小鼠中注射的 Aβ 寡聚体和细胞外 α-突触核蛋白原纤维[2]。
Anti-Mouse CD22 Antibody (Cy34.1) (100 μg/mouse，脑内纹状体注射，单剂量) 可耗竭表达 CD22 的细胞，并加剧视神经脊髓炎谱系障碍 (NMOSD) 小鼠的 NMOSD 病理[3]。
Anti-Mouse CD22 Antibody (Cy34.1) (10 mg/kg，静脉注射，在诱导 NMOSD 前三天给药) 可耗竭 NMOSD 小鼠中的 B 细胞[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Neuromyelitis optica spectrum disorder (NMOSD) mice models[1]
Dosage: 100 μg/mouse
Administration: Intrastriatally injection, a single dose
Result: Increased the lesion volume.
Augmented the loss of GFAP, AQP4, and MBP expression.
Augmented the inflammatory activity of microglia.
基因 ID

12483  [NCBI]

Accession

P35329-1
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse CD22 Antibody (Cy34.1) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD22 Antibody (Cy34.1)CD22Siglec 2B cellsMicroglialAβα-synucleinAlzheimer's diseaseNeuromyelitisInhibitorinhibitorinhibit

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