2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Anti-Mouse CD45RB Antibody (MB23G2)

Anti-Mouse CD45RB Antibody (MB23G2) 

目录号: HY-P990267
技术支持

Anti-Mouse CD45RB Antibody (MB23G2) 是一种源自大鼠的 IgG2a κ 型抗体抑制剂，靶向小鼠 CD45RB。Anti-Mouse CD45RB Antibody (MB23G2) 可阻断 CD45RB 并诱导移植耐受。Anti-Mouse CD45RB Antibody (MB23G2) 可用于感染、免疫和代谢性疾病的研究，如糖尿病和 Mem71 (H3N1) 病毒感染。

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Anti-Mouse CD45RB Antibody (MB23G2)

Anti-Mouse CD45RB Antibody (MB23G2) Chemical Structure

1.  客户无需承担相应的运输费用。

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Anti-Mouse CD45RB Antibody (MB23G2) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD45RB Antibody (MB23G2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD45RB. Anti-Mouse CD45RB Antibody (MB23G2) blocks CD45RB and induces transplantation tolerance. Anti-Mouse CD45RB Antibody (MB23G2) can be used for the researches of infection, immunology and metabolic disease, such as diabetes and Mem71 (H3N1) virus-infection[1][2].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD45RB Antibody (MB23G2) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CD45RB Antibody (MB23G2) (100 μg，静脉注射，在第 -1、0 和 5 天给药) 可使链脲佐菌素 (HY-13753) 诱导的患有糖尿病的胰岛移植的小鼠血糖正常化并延长其存活时间[1]。
Anti-Mouse CD45RB Antibody (MB23G2) (200 μg，腹腔注射，感染前 1 天给药，之后每 3 天给药一次) 可延缓 Mem71 (H3N1) 病毒感染小鼠的病毒清除[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Streptozotocin (HY-13753)-induced diabetic mice with Islet grafts[1]
Dosage: 100 μg
Administration: Intravenously injection, at days -1, 0, and 5
Result: Became normoglycemic within 3 days and prolonged survival.
Reduced IL-2, IFN-α,and IL-4 mRNA amounts.
Decreased white blood cell counts on day 3 and 7.
Reduced the CD45RBbright population for a week, but the population had already partially returned 5 days after the last injection.
Animal Model: Mem71 (H3N1) virus-infected mice models[2]
Dosage: 200 μg
Administration: Intraperitoneally injection, 1 day prior to infection and thereafter every 3 days
Result: Showed delayed viral clearance.
Showed fewer T cells were present in both MLN and lung.
Reduced total influenza-specific CD8+ T cells.
Delayed the humoral response.
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse CD45RB Antibody (MB23G2) 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD45RB Antibody (MB23G2)PhosphataseCD45CD45RBDiabetesMem71 (H3N1)Islet graftsInhibitorinhibitorinhibit

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