2. Immunology/Inflammation
  3. CD47
  4. Anti-Mouse CD47/IAP Antibody (MIAP301)

Anti-Mouse CD47/IAP Antibody (MIAP301) 

目录号: HY-P990131 纯度: 95.00%
COA 技术支持

Anti-Mouse CD47/IAP Antibody (MIAP301) 是一种抗小鼠 CD47/IAP IgG2a 单克隆抗体。Anti-Mouse CD47/IAP Antibody (MIAP301) 能有效阻断 CD47 信号传导并增强巨噬细胞吞噬功能。Anti-Mouse CD47/IAP Antibody (MIAP301) 可以增加免疫细胞的浸润。Anti-Mouse CD47/IAP Antibody (MIAP301) 恢复髓系细胞吞噬功能并减轻 B 细胞抑制。Anti-Mouse CD47/IAP Antibody (MIAP301) 可能会干扰伤口愈合。Anti-Mouse CD47/IAP Antibody (MIAP301) 可用于研究癌症, 炎症疾病和感染性疾病如黑色素瘤, 肠粘膜修复和脓毒症。

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Anti-Mouse CD47/IAP Antibody (MIAP301)

Anti-Mouse CD47/IAP Antibody (MIAP301) Chemical Structure

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Anti-Mouse CD47/IAP Antibody (MIAP301) 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD47/IAP Antibody (MIAP301) is an anti-mouse CD47/IAP IgG2a monoclonal antibody. Anti-Mouse CD47/IAP Antibody (MIAP301) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse CD47/IAP Antibody (MIAP301) can increase the infiltration of immune cells. Anti-Mouse CD47/IAP Antibody (MIAP301) restores the phagocytic function of myeloid cells and alleviate B cell inhibition. Anti-Mouse CD47/IAP Antibody (MIAP301) may interfere with wound healing. Anti-Mouse CD47/IAP Antibody (MIAP301) can be used for researches on cancer, inflammation and infection conditions such as melanoma, intestinal mucosal repair and sepsis[1][2][3].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CD47/IAP
体外研究
(In Vitro)

Anti-Mouse CD47/IAP Antibody (MIAP301) (10 μg/mL, 24 小时) 显著抑制上皮细胞迁移和伤口闭合[1]。
Anti-Mouse CD47/IAP Antibody (MIAP301) (0-4 h) 抑制 β1 整合素-FAK-SRc-p130Cas 信号通路，并降低 p-SrcY 416, p-FAKY 397, p-FAKY-Y861, p-p130Cas Y410 和 β1 整合素的水平[1]。
Anti-Mouse CD47/IAP Antibody (MIAP301) (0-100 μg/mL, 1 小时) 能够有效阻断 SM1 细胞的 CD47 并饱和其表位[2]。
Anti-Mouse CD47/IAP Antibody (MIAP301) (25 μg/mL, 2-4 小时) 显著增强巨噬细胞对 SM1 细胞的吞噬作用[2]。
Anti-Mouse CD47/IAP Antibody (MIAP301) (8 小时) 显著恢复髓系细胞对大肠杆菌的吞噬能力[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD47/IAP Antibody (MIAP301) 相关抗体:

Cell Migration Assay [1]

Cell Line: Epithelial cells
Concentration: 10 μg/mL
Incubation Time: 24 h
Result: Significant delayed in cell migration and wound closure.
体内研究
(In Vivo)

Anti-Mouse CD47/IAP Antibody (MIAP301) (400 μg，腹腔注射，单次剂量，伤口后 24 小时) 显著抑制了基于活检的粘膜伤口模型的雄性 C57Bl/6J 小鼠的粘膜伤口愈合[1]。
Anti-Mouse CD47/IAP Antibody (MIAP301) (100 μg，瘤内注射，每三天一次，直至研究结束) 与 Nexturastat A (HY-16699) 联合使用在携带 SM1 或 B16F10 肿瘤的雌性 C57BL/6 小鼠中显著抑制肿瘤生长并增加肿瘤微环境中的免疫细胞浸润[2]。
Anti-Mouse CD47/IAP Antibody (MIAP301) (2.5 mg/kg，静脉注射，单次剂量，盲肠结扎和穿刺 (CLP) 手术后 1 或 8 小时) 显著减少了克雷伯氏菌肺炎诱导的脓毒症 Balb/c 或 C57/BL6 小鼠血液和器官中的细菌数量并提高了存活率[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57Bl/6J mice with a biopsy-based mucosal wound (8-12 weeks)[1]
Dosage: 400 μg
Administration: Intraperitoneal injection (i.p.), single dose, 24 hours after the wound
Result: Caused delayed wound closure.
Animal Model: 0.75×106 SM1 or B16F10 cells injected female C57BL/6J mice (4-6 weeks)[2]
Dosage: 100 μg, combined with Nexturastat A (20 mg/kg, i.p., once every other day)
Administration: Intraperitoneal injection (i.p.), once every three days until the end of the study
Result: Significantly inhibited tumor volume.
Significantly increased infiltration of macrophages and natural killer (NK) cells in SM1 models.
Animal Model: Balb/c or C57/BL6 mice (8-10 weeks, 20-25 g) with a Klebsiella pneumonia-induced sepsis model[3]
Dosage: 2.5 mg/kg
Administration: Intravenous injection (i.v.), single dose, 1 or 8 hours after CLP surgery
Result: Significantly reduced bacterial load in blood and organs.
Improved survival rate (from 30% to 80%).
Reduced pathological damage to the lungs and kidneys.
Reduced the levels of inflammatory factors (TNF-α, IL-6, IL-1β, MCP-1).
基因 ID

16423  [NCBI]

Accession

Q61735-1
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CD47/IAP Antibody (MIAP301) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD47/IAP Antibody (MIAP301)CD47Cluster of Differentiation 47MER6OA3CD47/IAPmacrophageepithelial cellsSM1B16F10immune cellssepsisInhibitorinhibitorinhibit

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