2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse CD70 Antibody (FR70)

Anti-Mouse CD70 Antibody (FR70) 

目录号: HY-P990264 纯度: 95.00%
COA 技术支持

Anti-Mouse CD70 Antibody (FR70) 是一种源自大鼠的抗小鼠 CD70 IgG2b κ 型抗体抑制剂。Anti-Mouse CD70 Antibody (FR70) 可以减少 CD4 阳性、CD8 阳性 T 细胞和嗜酸性粒细胞。Anti-Mouse CD70 Antibody (FR70) 在过敏性肺部炎症和心脏移植小鼠模型中显示出强大的抗炎抗免疫的效果。

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Anti-Mouse CD70 Antibody (FR70)

Anti-Mouse CD70 Antibody (FR70) Chemical Structure

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Anti-Mouse CD70 Antibody (FR70) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD70 Antibody (FR70) is a rat-derived ant-mouse CD70 IgG2b κ type antibody inhibitor. Anti-Mouse CD70 Antibody (FR70) decreases CD4+, CD8+ T cells and eosinophils. Anti-Mouse CD70 Antibody (FR70) shows potent anti-inflammatory and anti-immune effects on allergic lung inflammation and cardiac transplant mice models[1][2][3].

同型

Rat IgG2b kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CD70
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD70 Antibody (FR70) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CD70 Antibody (FR70) (移植当天给予 500 μg 并在移植后第 2、4、6 天给予 250 μg，腹腔注射) 可显著延长移植物存活时间，并减少 CD4+ 和 CD8+ T 细胞在初次心脏移植小鼠同种异体移植物中的浸润[1]。
Anti-Mouse CD70 Antibody (FR70) (移植当天给予 500 μg 并在移植后第 1、3、5 天给予 250 μg，腹腔注射) 可诱导免疫耐受树突状细胞，使小鼠心脏同种异体移植物获得长期接受[2]。
Anti-Mouse CD70 Antibody (FR70) (300 μg，腹腔注射，第 0、2、4、7、11、14、16、18、22、25 和 28 天给药) 在过敏性肺部炎症小鼠模型中对炎症反应有显著抑制作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (H-2b) mice transplanted with fully major histocompatibility complexmismatched BALB/c (H-2d) vascularized cardiac grafts (6-8weeks)[1]
Dosage: 500 μg on the day of transplantation and 250 μg/dose on days 2, 4, and 6 posttransplantation
Administration: Intraperitoneally injection for 4 times
Result: Significant prolonged graft survival.
Reduced the infiltration of CD8+ and CD4+ T cells into the graft at day 8.
Showed low levels of CD8+ and CD4+ T cells in grafts harvested at day 15.
Resulted in lower levels of donor-specific IgG in the sera derived from peripheral blood.
Decreased percentage of splenic CD4+CD25+Foxp3+ cells.
Animal Model: C3H recipient mice with B6 heterotopic cardiac transplantation (8-12 weeks)[2]
Dosage: 500 μg on the day of transplantation and 250 μg/dose on days 1, 3, and 5 posttransplantation
Administration: Intraperitoneally injection for 4 times
Result: Induced long term cardiac allograft acceptance, with an MST of about 100 days.
Had a significantly smaller population of cytotoxic CD8+ T cells in graft-infiltrating lymphocytes and Spleen at day 7.
Decreased the expression of perforin and IFN-γ in the spleen.
Downregulated the expression of CD40, CD80, CD86, IL-6, IL-12β and MHC class II proteins and upregulated the levels of PD-L1, heme oxygenase-1 (HO-1) and indoleamine 2,3-dioxygenase (IDO1).
Generated regulatory cells (Tregs).
Increased the population of CD25+ Foxp3+ cells and levels of Foxp3 mRNA and IL-10 among the CD4+ graft-infiltrating lymphocytes.
Animal Model: Allergic lung inflammation mice models induced by ovalbumin (BALB/cByJJcl, female, 6-8 weeks) [3]
Dosage: 300μg
Administration: Intraperitoneally injection, at days 0, 2, 4, 7, 11, 14, 16, 18, 22, 25, and 28
Result: Significantly reduced the accumulation of eosinophils and lymphocytesand production of Th2 cytokines (IL-4 and IL-13) in BAL fluid and eosinophilia and mucus overproduction in the lung.
Reduced the ovalbumin-specific proliferative response and the levels of IL-4, IL-5, and IL-13.
Significantly inhibited the development of airway hyperreactivity, the accumulation of eosinophils in the lung, and the ovalbumin-specific proliferative response and production of Th2 cytokines (IL-5 and IL-13) in LN cells.
Inhibited the development of CD272 Th2 Cells.
基因 ID

21948  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CD70 Antibody (FR70) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD70 Antibody (FR70)Transmembrane GlycoproteinCD70CD4+ T cellsCD8+ T cellsEosinophilsLung inflammationCardiac transplantInhibitorinhibitorinhibit

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