2. Apoptosis
  3. Transferrin Receptor
  4. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) 

目录号: HY-P990791
技术支持

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) 是一种源自大鼠的 IgG2a κ 型抗体抑制剂，靶向小鼠 CD71/TfR1。Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) 可清除 CD71+ 细胞并抑制转铁蛋白受体。Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) 可用于癌症、感染、炎症和免疫学等方面的研究，如肺癌、淋巴细胞性脉络丛脑膜炎病毒 (LCMV) 感染和心脏移植。

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Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) Chemical Structure

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Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD71/TfR1. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can deplete CD71+ cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft[1][2][3][4].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CD71/TfR1
体外研究
(In Vitro)

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (10 μg/mL, 18-72 h) 可降低 2 型天然淋巴细胞 (ILC2s) 中转铁蛋白受体 1 的表达，并抑制转铁蛋白的摄取[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (150 μg，腹腔注射，连续 2 天每天一次) 可清除内毒素血症新生小鼠模型中 CD71+ 红系脾细胞，并增强细菌清除能力[1]。
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (0.5 or 1.0 mg/mouse，静脉注射，在肿瘤细胞接种后第 21 天) 抑制携带 Lewis 肺癌肿瘤的淋巴细胞性脉络丛脑膜炎病毒 (LCMV) 感染小鼠中转移的 P14 CD8+ T 细胞的抗病毒反应[2]。
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (100 μg，腹腔注射，每次鼻内激发前给药) 可减少 2 型固有淋巴细胞 (ILC2s) 依赖性气道炎症小鼠的肺部 ILC2s 聚集[3]。
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (100 μg，静脉注射，从第 0 天到第 3 天每天给药) 可延长心脏移植小鼠的移植物存活时间[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cardiac allograft mice models[1]
Dosage: 100 μg
Administration: Intravenously injection, at day 0 and 1
Result: Prolonged graft survival.
Increased the CTL response to donor-specific alloantigen.
Suppressed the MLR to donor-specific alloantigen.
Reduced B7-expressing cells.
Inhibited activation of allo-reactive T cells and migration of T cells into the allograft site.
Suppressed the IL-15 mRNA and increased the Th2 cytokine IL-4 mRNA expression.
基因 ID

22042  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)Transferrin ReceptorTfRCD71TransferrinTransferrin receptorLung cancerLCMVILC2sGraftInhibitorinhibitorinhibit

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